CK1-IN-1 - 10mM in DMSO , CAS No.1784751-20-7

CAS: 1784751-20-7 Cat. No.: C422174 Molecular Weight: 383.39

GRADE & PURITY 10mM in DMSO

Synonyms

PUN51207 | Compound 1CPyridine,4-​[2-​(1-​fluoro-​2-​naphthalenyl)​-​4-​(4-​fluorophenyl)​-​1H-​imidazol-​5-​yl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

CK1-IN-1 CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.

Targets

CK1δ (Cell-free assay); CK1ε (Cell-free assay); p38αMAPK (Cell-free assay) 15 nM; 16 nM; 73 nM

Specifications

Synonyms

PUN51207 | Compound 1CPyridine, 4-​[2-​(1-​fluoro-​2-​naphthalenyl)​-​4-​(4-​fluorophenyl)​-​1H-​imidazol-​5-​yl]​-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Canonical Smiles: C1=CC=C2C(=C1)C=CC(=C2F)C3=NC(=C(N3)C4=CC=NC=C4)C5=CC=C(C=C5)F
• IUPAC Name: 4-[2-(1-fluoronaphthalen-2-yl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine
• InChIKey: PUQAFIILJICJRR-UHFFFAOYSA-N
• INCHI: 1S/C24H15F2N3/c25-18-8-5-16(6-9-18)22-23(17-11-13-27-14-12-17)29-24(28-22)20-10-7-15-3-1-2-4-19(15)21(20)26/h1-14H,(H,28,29)
• Isomeric SMILES: C1=CC=C2C(=C1)C=CC(=C2F)C3=NC(=C(N3)C4=CC=NC=C4)C5=CC=C(C=C5)F
• Molecular Weight: 383.39
• Reaxy-Rn: 28532087
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28532087&ln=

Chemical and Physical Properties

• Molecular Weight: 383.400 g/mol
• XLogP3: 5.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 383.123 Da
• Monoisotopic Mass: 383.123 Da
• Topological Polar Surface Area: 41.600 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 532.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1