Dihydroethidium - 10mM in DMSO , CAS No.104821-25-2

CAS: 104821-25-2 Cat. No.: D420461 Molecular Weight: 315.41 Beilstein Registry Number: 5107482

GRADE & PURITY 10mM in DMSO

Synonyms

Hydroethidine | J-100119 | AKOS015915966 | FT-0624954 | PH011085 | Hydroethidine;PD-MY 003 | Dihydroethidium - CAS 38483-26-0 | Enoxacinum (Latin) | NSC-408120 | 5-ethyl-6-phenyl-6H-phenanthridine-3,8-diamine | Q3027884 | BCP15712 | SCHEMBL79004 | 5-ethyl

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Hydroethidine operates effectively as a probe for measurement of reactive oxygen species. The dye enters cells freely and is dehydrogenated to ethidium bromide. The probe has been used extensively with NK cell and as a vital dye for identification of proliferation and hypoxic cells in tumors. Studies have been performed using neutrophils and endothelial cells as well as HL60 cells and macrophages. A major advantage of this probe is its ability to distinguish between superoxide and H2O2. Fluorescence emission occurs at around 600 nm.
Redox indicator. Blue fluorescence until oxidized to ethidium

Specifications

Synonyms

Hydroethidine | J-100119 | AKOS015915966 | FT-0624954 | PH011085 | Hydroethidine;PD-MY 003 | Dihydroethidium - CAS 38483-26-0 | Enoxacinum (Latin) | NSC-408120 | 5-ethyl-6-phenyl-6H-phenanthridine-3, 8-diamine | Q3027884 | BCP15712 | SCHEMBL79004 | 5-ethyl

Specifications & Purity

10mM in DMSO

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CCN1C(C2=C(C=CC(=C2)N)C3=C1C=C(C=C3)N)C4=CC=CC=C4
• IUPAC Name: 5-ethyl-6-phenyl-6H-phenanthridine-3,8-diamine
• InChIKey: XYJODUBPWNZLML-UHFFFAOYSA-N
• INCHI: 1S/C21H21N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,21H,2,22-23H2,1H3
• Isomeric SMILES: CCN1C(C2=C(C=CC(=C2)N)C3=C1C=C(C=C3)N)C4=CC=CC=C4
• WGK Germany: 3
• Molecular Weight: 315.41
• Beilstein: 5107482
• Reaxy-Rn: 5107482
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5107482&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Quinolines and derivatives
      • Subclass Phenylquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Quinolines and derivatives
• Subclass: Phenylquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylquinolines
• Alternative Parents: Phenanthridines and derivatives Aminoquinolines and derivatives Dialkylarylamines Aralkylamines Benzene and substituted derivatives Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylquinoline - Benzoquinoline - Phenanthridine - Aminoquinoline - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Tertiary amine - Azacycle - Amine - Primary amine - Hydrocarbon derivative - Organonitrogen compound - Organopnictogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Air sensitive.Light sensitive.
• Molecular Weight: 315.400 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 315.174 Da
• Monoisotopic Mass: 315.174 Da
• Topological Polar Surface Area: 55.300 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 419.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

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