Diphemanil Methylsulfate - 10mM in DMSO , Muscarinic acetylcholine receptor M1 antagonist, CAS No.62-97-5, Muscarinic acetylcholine receptor M1 antagonist

CAS: 62-97-5 Cat. No.: D409097 Molecular Weight: 405.51 EC Number: 200-552-4

GRADE & PURITY 10mM in DMSO

Synonyms

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
In vitro

Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth musclespasmolytic activity.

In vivo

The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Piperidinium, 4-(diphenylmethylene)-1, 1-dimethyl-, methyl sulfate (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Mechanism of action

Muscarinic acetylcholine receptor M1 antagonist

Names and Identifiers

• Isomeric SMILES: C[N+]1(CCC(=C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C.COS(=O)(=O)[O-]
• RTECS: TN5075000
• Molecular Weight: 405.51
• Reaxy-Rn: 3842254
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3842254&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 34 mg/mL (113.92 mM); Ethanol: 28 mg/mL (93.81 mM); Water: Insoluble
• Melt Point(°C): 194 °C