DOTAGA-anhydride - ≥95% , CAS No.1375475-53-8

CAS: 1375475-53-8 Cat. No.: D1424089 Molecular Weight: 458.46

GRADE & PURITY ≥95%

Synonyms

DOTAGA-Anhydride | 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid,10-(tetrahydro-2,6-dioxo-2H-pyran-3-yl)Chemicalbook- | 2,2',2''-(10-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triaceticacid

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.

Specifications

Synonyms

DOTAGA-Anhydride | 1, 4, 7, 10-Tetraazacyclododecane-1, 4, 7-triaceticacid, 10-(tetrahydro-2, 6-dioxo-2H-pyran-3-yl)Chemicalbook- | 2, 2', 2''-(10-(2, 6-Dioxotetrahydro-2H-pyran-3-yl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-triyl)triaceticacid

Specifications & Purity

≥95%

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Molecular Weight: 458.46