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· · COA & SDS available for every product · Same-day shipping on in-stock items FG-2216 - 10mM in DMSO , CAS No.223387-75-5
GRADE & PURITY 10mM in DMSO
Synonyms
(((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid | 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide | A899534 | Isoquinoline 3 | 4ie6 | SCHEMBL522744 | DB08687 | IOX3;YM311 | FG 2216 | SCHEMBL166144 | [(1-Chloro-4-hydro
Shipped In
Dry ice packs + Cold packs
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Why this grade 10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Information
FG-2216 FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 . Phase 2.
Targets
PHD2 (Cell-free assay) 3.9 μM
In vitro
FG-2216 shows the ability to stabilize HIF-α to stimulate EPO secretion.
In vivo
In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression.
Specifications Synonyms
(((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid | 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide | A899534 | Isoquinoline 3 | 4ie6 | SCHEMBL522744 | DB08687 | IOX3;YM311 | FG 2216 | SCHEMBL166144 | [(1-Chloro-4-hydro
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2.
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Product Properties ALogP 1.337 hba_count 3 HBD Count 2 Rotatable Bond 3
Names and Identifiers Canonical Smiles C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O IUPAC Name 2-[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]acetic acid InChIKey OUQVKRKGTAUJQA-UHFFFAOYSA-N INCHI 1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) Isomeric SMILES C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O Molecular Weight 280.66 Reaxy-Rn 10565114 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10565114&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives - N-acyl-alpha amino acids and derivatives Direct Parent N-acyl-alpha amino acids Alternative Parents Isoquinolines and derivatives Pyridinecarboxylic acids and derivatives 2-heteroaryl carboxamides 2-halopyridines Hydroxypyridines Aryl chlorides Benzenoids Heteroaromatic compounds Vinylogous acids Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organonitrogen compounds Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Organic oxides Organochlorides Molecular Framework Aromatic heteropolycyclic compounds Substituents N-acyl-alpha-amino acid - Isoquinoline - Pyridine carboxylic acid or derivatives - 2-heteroaryl carboxamide - 2-halopyridine - Hydroxypyridine - Aryl chloride - Aryl halide - Pyridine - Benzenoid - Heteroaromatic compound - Vinylogous acid - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Carbonyl group - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties DMSO(mg / mL) Max Solubility 56 DMSO(mM) Max Solubility 199.52968 Water(mg / mL) Max Solubility ＜1 Molecular Weight 280.660 g/mol XLogP3 2.500 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5 Rotatable Bond Count 3 Exact Mass 280.025 Da Monoisotopic Mass 280.025 Da Topological Polar Surface Area 99.500 Ų Heavy Atom Count 19 Formal Charge 0 Complexity 366.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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