Fmoc-6-aminohexanoic acid - ≥98% , CAS No.88574-06-5

CAS: 88574-06-5 Cat. No.: F117709 Molecular Weight: 353.41 Beilstein Registry Number: 5883220 EC Number: 627-935-2

GRADE & PURITY ≥98%

Synonyms

Fmoc-epsilon-Acp-OH | N-Fmoc-6-aminocaproic acid | FT-0688934 | SMR000555403 | DS-8037 | MFCD00077045 | 6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid | Fmoc-?-Acp-OH | Z1123719981 | AKOS001623857 | I10487 | 6-(9H-Fluoren-9-ylmethoxycarbonylam

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Product Application:
6-(Fmoc-amino)hexanoic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Specifications

Synonyms

Fmoc-epsilon-Acp-OH | N-Fmoc-6-aminocaproic acid | FT-0688934 | SMR000555403 | DS-8037 | MFCD00077045 | 6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid | Fmoc-?-Acp-OH | Z1123719981 | AKOS001623857 | I10487 | 6-(9H-Fluoren-9-ylmethoxycarbonylam

Specifications & Purity

≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488192995
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488192995
• Canonical Smiles: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCCCCC(=O)O
• IUPAC Name: 6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
• InChIKey: FPCPONSZWYDXRD-UHFFFAOYSA-N
• INCHI: 1S/C21H23NO4/c23-20(24)12-2-1-7-13-22-21(25)26-14-19-17-10-5-3-8-15(17)16-9-4-6-11-18(16)19/h3-6,8-11,19H,1-2,7,12-14H2,(H,22,25)(H,23,24)
• Isomeric SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCCCCC(=O)O
• WGK Germany: 3
• Molecular Weight: 353.41
• Beilstein: 5883220
• Reaxy-Rn: 5883220
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5883220&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Fluorenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Fluorenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Fluorenes
• Alternative Parents: Medium-chain fatty acids Amino fatty acids Carbamate esters Organic carbonic acids and derivatives Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Fluorene - Medium-chain fatty acid - Amino fatty acid - Fatty acyl - Fatty acid - Carbamic acid ester - Carbonic acid derivative - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organonitrogen compound - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)

Discover Target: KMT2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in 1% acetic acid, water and 1mmol in 2mL DMF clearly soluble
• Molecular Weight: 353.400 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 353.163 Da
• Monoisotopic Mass: 353.163 Da
• Topological Polar Surface Area: 75.600 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 459.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Peng Wang, Sihan Wang, Li Chen, Wenting Wang, Baohui Wang, Yunwen Liao.  (2020)  A novel peptide-based fluorescent probe for sensitive detection of zinc (II) and its applicability in live cell imaging.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:32526399] [10.1016/j.saa.2020.118549]

2. Jianxu Zhou, Taotao Huo, Junxian Miu, Ziyi Wang, Xiaoyu Shan, Jiaqi Song, Yuquan Bai, Shuichu Hao, Chun Zhang, Shichang Liu, Biao Wang, Guanying Li.  (2025)  Bone-Adhesive Peptide Hydrogel Loaded with Cisplatin for Postoperative Treatment of Osteosarcoma.  ACS Applied Materials & Interfaces,      [PMID:39908045] [10.1021/acsami.4c19608]

3. Jun Liu, Xiaoyu Hu, Guanghao Yu, Qingrong Wang, Liwei Gu, Jianying Shen, Qinghe Zhao, Hao Sun, Shi Wang, Zhongyuan Guo, Yu Zhao, Hai Ma.  (2024)  Doxorubicin-based ENO1 targeted drug delivery strategy enhances therapeutic efficacy against colorectal cancer.  BIOCHEMICAL PHARMACOLOGY,      [PMID:38641307] [10.1016/j.bcp.2024.116220]