Moligand™,10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 19 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
In vitro
Gastrodin is the most important and effective ingredient extracted from Chinese natural herbal Gastrodia elata. Gastrodin (30, 40, and 60 mM) significantly attenuates levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-kappaB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. However, It also upregulates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling, resulting in the inhibitory effects NF-kappaB and MAPKs activation in H9c2 cardiomyocytes.
In vivo
Gastrodin at 5 mg/kg can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, GAS can facilitate memory consolidation and retrieval, but not acquisition. LD50: Mice >1000mg/kg (i.v.)
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | C1=CC(=CC=C1CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O |
|---|---|
| Molecular Weight | 286.28 |
| Reaxy-Rn | 25441801 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25441801&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Specific Rotation[α] | -66.0 to -70.0 deg(C=1,H2O) |
|---|---|
| Melt Point(°C) | 154-155°C |
| 1. Jiang-Long Shi, Li-Yun Liu, Yu-Ting Dong, Tao Shen. (2023) Gastrodin Ameliorates Knee Joint Inflammation and Pain in Osteoarthritis Rats and Prevents Chondrocyte Injury by Regulating PI3K/Akt/FoxO1 Pathway. Pharmacognosy Magazine, [PMID:] [10.1177/09731296231203860] |
| 2. Baolin Huang, Zimin Lin, Zhenzhen Chen, Jiasheng Chen, Birui Shi, Jingjing Jia, Yuan Li, Yueqing Pan, Yuntao Liang, Zheng Cai. (2023) Strain differences in the drug transport capacity of intestinal glucose transporters in Sprague–Dawley versus Wistar rats, C57BL/6J versus Kunming mice. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:37254285] [10.1016/j.ijpharm.2023.123000] |
| 3. Jin-Jin Song, Hui Li, Nan Wang, Xiao-Yan Zhou, Yan Liu, Zhen Zhang, Qian Feng, Yu-Ling Chen, Dan Liu, Jia Liang, Xiang-Yu Ma, Xiang-Ru Wen, Yan-Yan Fu. (2022) Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p. Frontiers in Pharmacology, [PMID:36569291] [10.3389/fphar.2022.1044375] |
| 4. Yin Hua, Hu Tiandong, Zhuang Yibin, Liu Tao. (2020) Metabolic engineering of Saccharomyces cerevisiae for high-level production of gastrodin from glucose. Microbial Cell Factories, 19 (1): (1-12). [PMID:33243241] [10.1186/s12934-020-01476-0] |
| 5. Limin Li, Bin Hao, Yulong Zhang, Shen Ji, Guixin Chou. (2020) Metabolite Profiling and Distribution of Militarine in Rats Using UPLC-Q-TOF-MS/MS. MOLECULES, 25 (5): (1082). [PMID:32121087] [10.3390/molecules25051082] |
| 6. Lianfang Chen, Junjie Ou, Hongwei Wang, Zhongshan Liu, Mingliang Ye, Hanfa Zou. (2016) Tailor-Made Stable Zr(IV)-Based Metal–Organic Frameworks for Laser Desorption/Ionization Mass Spectrometry Analysis of Small Molecules and Simultaneous Enrichment of Phosphopeptides. ACS Applied Materials & Interfaces, [PMID:27427857] [10.1021/acsami.6b06225] |
| 7. Yanfen Bai, Hua Yin, Huiping Bi, Yibin Zhuang, Tao Liu, Yanhe Ma. (2016) De novo biosynthesis of Gastrodin in Escherichia coli. METABOLIC ENGINEERING, [PMID:26804288] [10.1016/j.ymben.2016.01.002] |
| 8. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu. (2015) Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase. TALANTA, [PMID:26695288] [10.1016/j.talanta.2015.09.009] |
| 9. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang. (2025) An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds. FOOD CHEMISTRY, [PMID:40120314] [10.1016/j.foodchem.2025.143873] |
| 10. Chenran Xin, Pinhui Jia, Yan Zhao, Zhiqiang Cheng, Wencong Liu, Peng Di, Wei Li, Hongyan Zhu. (2025) Antioxidant effects of Gastrodia elata polysaccharide-based hydrogels loaded with puerarin/gelatin microspheres for D-galactose-induced aging-skin wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39805458] [10.1016/j.ijbiomac.2025.139809] |
| 11. Lin Ge, Yu Xia, Wenxin Xu, Ruobing Jia, Tingting Zhang. (2025) Efficient Biosynthesis of Gastrodin by UDP-Glycosyltransferase from Rauvolfia serpentina. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, [PMID:40147927] [10.4014/jmb.2501.01002] |
| 12. Sun Hao-Fei, Cui Yuan-Yuan, Li Hong-Liang, Yang Cheng-Xiong. (2023) Click postsynthesis of microporous organic network@silica composites for reversed-phase/hydrophilic interaction mixed-mode chromatography. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (18): (4533-4543). [PMID:37017725] [10.1007/s00216-023-04680-0] |
| 13. Qiang Yin, Ran Yan, Yan Wang, Jia Yu. (2023) Gastrodin from Gastrodia elata attenuates acute myocardial infarction by suppressing autophagy: Key role of the miR-30a-5p/ATG5 pathway. Journal of Functional Foods, [PMID:] [10.1016/j.jff.2023.105429] |
| 14. Yuhong Wang, Kaixuan Luo, Junrui Li, Yehui Liao, Chengde Liao, Wen-Shiang Chen, Moxian Chen, Lijuan Ao. (2022) Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease. Frontiers in Cellular Neuroscience, [PMID:35656407] [10.3389/fncel.2022.884788] |
| 15. He Sun, Miao Li, Yunling Li, Na Zheng, Jiaxin Li, Xiang Li, Yingying Liu, Qianyun Ji, Liping Zhou, Jingwen Su, Wanxu Huang, Zhongbo Liu, Peng Liu, Libo Zou. (2024) Gastrodin Improves the Activity of the Ubiquitin–Proteasome System and the Autophagy–Lysosome Pathway to Degrade Mutant Huntingtin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (14): (7709). [PMID:39062952] [10.3390/ijms25147709] |
| 16. Ge Xinyu, Wu Bozhao, Dou Xiaohui, Sun Mingchen, Wu Ji-ao, Sun Daqing. (2025) Gastrodin alleviates loperamide-induced slow transit constipation in mice by modulating the MAPK signaling pathway. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, [PMID:41134354] [10.1007/s00210-025-04763-y] |
| 17. Ruijing Li, Weili Yang, Lijuan Zheng, Xingxue Yan, Cuihua Liu, Yaodong Zhang, Jitong Li. (2025) Gastrodin alleviates alcohol-induced developmental and neurotoxic effects in zebrafish larvae by suppressing ferroptosis via regulating the Nrf2/GPX4 signaling pathway. TOXICOLOGY AND APPLIED PHARMACOLOGY, [PMID:41371372] [10.1016/j.taap.2025.117684] |
| 18. Hong Ding, Wen-Xuan Wang, Qiong-Dan Liang, Chuan-Feng Tang, Tang-Di Xu, Zi-An Miao, Bang-Xing Han, Ling-Dong Kong. (2026) Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered Bok mRNA degradation. International Journal of Biological Sciences, 22 (3): (1162). [PMID:41608624] [10.7150/ijbs.120307] |
| 19. Haili Zhang, Ling Li, Zhihuang Zhao, Meidan Wang, Yangyan Ge, Shuqin Lu, Min Hu, Chenghong Xiao, Menglan Luo, Ting Lei, Liangyuan Li, Jinqiang Zhang. (2026) Systems pharmacology reveals the mechanism underlying gastrodiae rhizoma in improving stress-induced cognitive impairment: Protecting hippocampal synapses from excessive microglia-mediated pruning. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:] [10.1016/j.jep.2026.121482] |
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