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GNE-9822 , CAS No.1557232-32-2
AVAILABLE TO ORDER
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
GNE-9822 is a potent, orally active and selective ITK inhibitor with a K i value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma.
In Vitro
GNE-9822 (compound 28) inhibits the phosphorylation of PLCγ with an IC 50 value of 55 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
GNE-9822 (compound 28; po and iv; 1 and 5 mg/kg) has good bioavailability and halflives observed in mouse and rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/c mouse and Sprague-Dawley rats Dosage: 1 and 5 mg/kg Administration: po (5 mg/kg) and iv (1 mg/kg) Result: 1.19 species route dose volume (mL/kg) dose (mg/kg) C max (μM) AUC (μM·h) Cl (mL/min/kg) T 1/2 (h) V ss (L/kg) %F mouse (BALB/c) IV 1.0 1.0 1.5 40 2.9 10 mouse (BALB/c) PO 5.0 50 3.8 2.7 36 Animal Model: BALB/c mouse and Sprague-Dawley rats Dosage: 1 and 5 mg/kg Administration: po (5 mg/kg) and iv (1 mg/kg) Result: 1.19 species route dose volume (mL/kg) dose (mg/kg) C max (μM) AUC (μM·h) Cl (mL/min/kg) T 1/2 (h) V ss (L/kg) %F rat (Sprague-Dawley IV 1.0 1.0 0.6 70 3.0 14 rat (Sprague-Dawley PO 2.0 5.0 0.2 1.1 40
Form:Solid
Specifications
Biochemical and Physiological Mechanisms
GNE-9822 is a potent, orally active and selective ITK inhibitor with a K i value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Names and Identifiers
| Molecular Weight | 420.55 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 62.5 mg/mL (148.61 mM; Need ultrasonic) |
|---|
Solution Calculators
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