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· · COA & SDS available for every product · Same-day shipping on in-stock items GSK 2193874 - Moligand™, ≥98% , Channel blocker of TRPV4, CAS No.1336960-13-4, Channel blocker of TRPV4
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
GSK2193874 | GSK-2193874 | GTPL6465 | NCGC00370767-01 | 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide | BS-15222 | AC-33151 | SCHEMBL2404540 | BDBM50232797 | 7-bromo-N-(1-phenylcycl
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
GSK2193874 | GSK-2193874 | GTPL6465 | NCGC00370767-01 | 3-([1, 4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide | BS-15222 | AC-33151 | SCHEMBL2404540 | BDBM50232797 | 7-bromo-N-(1-phenylcycl
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Potent and selective TRPV4 antagonist (IC50values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarctionin vivomodels. Selective over a pane
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
CHANNEL BLOCKER
Mechanism of action
Channel blocker of TRPV4
Names and Identifiers Pubchem Sid 504771262 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771262 Canonical Smiles C1CCN(CC1)C2CCN(CC2)CC3=C(C4=C(C=C(C=C4)Br)N=C3C5=CC(=CC=C5)C(F)(F)F)C(=O)NC6(CC6)C7=CC=CC=C7 IUPAC Name 7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide InChIKey UIVOZBSCHXCGPS-UHFFFAOYSA-N INCHI 1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46) Isomeric SMILES C1CCN(CC1)C2CCN(CC2)CC3=C(C4=C(C=C(C=C4)Br)N=C3C5=CC(=CC=C5)C(F)(F)F)C(=O)NC6(CC6)C7=CC=CC=C7 Alternate CAS 1336960-13-4 MeSH Entry Terms 7-bromo-N-(1-phenylcyclopropyl)-3-((4-piperidin-1-ylpiperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide;GSK2193874 Molecular Weight 691.62 Reaxy-Rn 21962100 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21962100&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Quinolines and derivatives Subclass Phenylquinolines Intermediate Tree Nodes Not available Direct Parent Phenylquinolines Alternative Parents Quinoline carboxamides Phenylpyridines Haloquinolines Trifluoromethylbenzenes Pyridinecarboxylic acids and derivatives Aminopiperidines Aralkylamines Aryl bromides Heteroaromatic compounds Secondary carboxylic acid amides Trialkylamines Amino acids and derivatives Azacyclic compounds Organobromides Organic oxides Hydrocarbon derivatives Organooxygen compounds Alkyl fluorides Organofluorides Molecular Framework Aromatic heteropolycyclic compounds Substituents Phenylquinoline - Quinoline-4-carboxamide - 2-phenylpyridine - Haloquinoline - Trifluoromethylbenzene - Pyridine carboxylic acid or derivatives - 4-aminopiperidine - Aralkylamine - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Piperidine - Pyridine - Benzenoid - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Amino acid or derivatives - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Organobromide - Organohalogen compound - Organooxygen compound - Amine - Alkyl halide - Alkyl fluoride - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic nitrogen compound - Organofluoride - Organonitrogen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 34.58, Max Conc. mM: 50 Molecular Weight 691.600 g/mol XLogP3 7.800 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 7 Exact Mass 690.218 Da Monoisotopic Mass 690.218 Da Topological Polar Surface Area 48.500 Ų Heavy Atom Count 46 Formal Charge 0 Complexity 1020.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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