GSK2850163 - 10mM in DMSO , CAS No.2121989-91-9

CAS: 2121989-91-9 Cat. No.: G656144 Molecular Weight: 446.41 PubChem CID: 73291790

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha ( IRE1α ) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively.

In Vitro

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC 50 =4.4 μM) and FGFR1 V561M (IC 50 =17 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 20 nM (IRE1α kinase activity), 200 nM (IRE1α RNase activity)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha ( IRE1α ) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=CC=C(C=C1)CNC(=O)N2CCC[C@@]3(C2)CCN(C3)CC4=CC(=C(C=C4)Cl)Cl
• PubChem CID: 73291790
• Molecular Weight: 446.41