His-Gly - ≥98%(HPLC) , CAS No.2578-58-7

CAS: 2578-58-7 Cat. No.: H121428 Molecular Weight: 212.21

GRADE & PURITY ≥98%(HPLC)

Synonyms

His-Gly | 2-chloranyl-5-(1~{H}-1,2,3,4-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide | AKOS016014021 | H-HIS-GLY-OH | 2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]acetic acid | AB00698544-09 | L-His-Gly | HG dipeptide | H-G Dipepti

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

His-Gly | 2-chloranyl-5-(1~{H}-1, 2, 3, 4-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide | AKOS016014021 | H-HIS-GLY-OH | 2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]acetic acid | AB00698544-09 | L-His-Gly | HG dipeptide | H-G Dipepti

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: C1=C(NC=N1)CC(C(=O)NCC(=O)O)N
• IUPAC Name: 2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]acetic acid
• InChIKey: LYCVKHSJGDMDLM-LURJTMIESA-N
• INCHI: 1S/C8H12N4O3/c9-6(1-5-2-10-4-12-5)8(15)11-3-7(13)14/h2,4,6H,1,3,9H2,(H,10,12)(H,11,15)(H,13,14)/t6-/m0/s1
• Isomeric SMILES: C1=C(NC=N1)C[C@@H](C(=O)NCC(=O)O)N
• WGK Germany: 3
• Molecular Weight: 212.21
• Reaxy-Rn: 4843747
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4843747&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Not available
• Direct Parent: Peptides
• Alternative Parents: N-acyl-alpha amino acids Imidazolyl carboxylic acids and derivatives Aralkylamines Heteroaromatic compounds Amino acids Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboxylic acids Carboximidic acids Azacyclic compounds Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha peptide - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Alpha-amino acid or derivatives - Imidazolyl carboxylic acid derivative - Aralkylamine - Azole - Imidazole - Heteroaromatic compound - Amino acid or derivatives - Amino acid - Carboximidic acid - Carboximidic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organopnictogen compound - Carbonyl group - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Primary amine - Amine - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
• External Descriptors: dipeptide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACE Tclin Angiotensin-converting enzyme (1423 Activities)

Discover Target: ACE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 Activities)

Discover Target: SLC15A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdc Histidine decarboxylase (50 Activities)

Discover Target: Hdc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 212.210 g/mol
• XLogP3: -3.900
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 212.091 Da
• Monoisotopic Mass: 212.091 Da
• Topological Polar Surface Area: 121.000 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 246.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jucai Xu, Lin Zheng, Lianzhu Lin, Baoguo Sun, Guowan Su, Mouming Zhao.  (2018)  Stop-flow reversed phase liquid chromatography × size-exclusion chromatography for separation of peptides.  ANALYTICA CHIMICA ACTA,      [PMID:29605129] [10.1016/j.aca.2018.02.025]

2. Jucai Xu, Dongxiao Sun-Waterhouse, Chaoying Qiu, Mouming Zhao, Baoguo Sun, Lianzhu Lin, Guowan Su.  (2017)  Additional band broadening of peptides in the first size-exclusion chromatographic dimension of an automated stop-flow two-dimensional high performance liquid chromatography.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:28951053] [10.1016/j.chroma.2017.09.025]