L 012 sodium salt - ≥98%(HPLC) , CAS No.143556-24-5

CAS: 143556-24-5 Cat. No.: L287250 Molecular Weight: 310.67 EC Number: 811-221-4

GRADE & PURITY ≥98%(HPLC)

Synonyms

sodium 8-amino-5-chloro-4-oxo-7-phenyl-3,4-dihydropyrido[3,4-d]pyridazin-1-olate | L012 sodium | sodium;8-amino-5-chloro-4-oxo-7-phenyl-3H-pyrido[3,4-d]pyridazin-1-olate | L 012 sodium salt | L012

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Product Describtion:

L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2•−) and identify Nox inhibitors.

Specifications

Synonyms

sodium 8-amino-5-chloro-4-oxo-7-phenyl-3, 4-dihydropyrido[3, 4-d]pyridazin-1-olate | L012 sodium | sodium;8-amino-5-chloro-4-oxo-7-phenyl-3H-pyrido[3, 4-d]pyridazin-1-olate | L 012 sodium salt | L012

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Activein vitroandin vivo.

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504773670
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773670
• Canonical Smiles: C1=CC=C(C=C1)C2=C(C3=C(C(=O)NN=C3[O-])C(=N2)Cl)N.[Na+]
• IUPAC Name: sodium;8-amino-5-chloro-4-oxo-7-phenyl-3H-pyrido[3,4-d]pyridazin-1-olate
• InChIKey: IGEUYSJHQQCEFP-UHFFFAOYSA-M
• INCHI: 1S/C13H9ClN4O2.Na/c14-11-8-7(12(19)17-18-13(8)20)9(15)10(16-11)6-4-2-1-3-5-6;/h1-5H,15H2,(H,17,19)(H,18,20);/q;+1/p-1
• Isomeric SMILES: C1=CC=C(C=C1)C2=C(C3=C(C(=O)NN=C3[O-])C(=N2)Cl)N.[Na+]
• Molecular Weight: 310.67
• Reaxy-Rn: 30826882
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30826882&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pyridines and derivatives
      • Subclass Phenylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pyridines and derivatives
• Subclass: Phenylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridines
• Alternative Parents: Pyridazinones 2-halopyridines Aminopyridines and derivatives Aryl chlorides Benzene and substituted derivatives Vinylogous amides Heteroaromatic compounds Lactams Azacyclic compounds Organic metal halides Hydrocarbon derivatives Organic sodium salts Organic zwitterions Primary amines Organochlorides Organic oxides Organooxygen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 2-phenylpyridine - Aminopyridine - 2-halopyridine - Pyridazinone - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Pyridazine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Lactam - Organic metal halide - Azacycle - Organic alkali metal salt - Primary amine - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Amine - Organic oxygen compound - Organic sodium salt - Organic zwitterion - Organic salt - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: 6.21, Max Conc. mM: 20; Solvent:DMSO, Max Conc. mg/mL: 31.07, Max Conc. mM: 100
• Sensitivity: Moisture sensitive；Light sensitive

References

1. Ranran Guo, Ruixun Chen, Zhenhang Rao, Lugui Wang, Jianing Xi, Yu Zhang, Weisheng Guo, Ye Tian.  (2025)  Boosting Checkpoint Blockade Immunotherapy with T Cell Membrane Redox Homeostasis Regulation and Deep Learning Enhanced NIR-II Imaging.  Advanced Healthcare Materials,      [PMID:40583483] [10.1002/adhm.202500769]

2. Ling Shuai, Xiaojun Wang, Xudong Wen, Cong Peng, Tian Dong, Jiejuan Lai, Ling Yao, Shijun Fan, Changchun Zhao, Leida Zhang, Yujun Zhang, Xiang Xiong.  (2026)  A Multifunctional Nanoplatform for Treating Hepatic Ischemia–Reperfusion Injury by Modulating the Nrf2 and NF-κB Pathways.  ACS Applied Materials & Interfaces,      [PMID:41487044] [10.1021/acsami.5c20754]