L-Azetidine-2-carboxylic acid - Moligand™, ≥99% , CAS No.2133-34-8

CAS: 2133-34-8 Cat. No.: A124088 Molecular Weight: 101.1 Beilstein Registry Number: 80680 EC Number: 218-362-5

GRADE & PURITY Moligand™, ≥99%

Synonyms

(S)-2-Azetidinecarboxylic acid | 02A | 2-Azetidinecarboxylic acid, (2S)- | AM20090185 | C08267 | (S)-Azetidine-2-carboxylicacid | CHEBI:6198 | L-Azetidine 2-carboxylic acid | SR-01000075656-1 | UNII-5GZ3E0L9ZU | (S)-(-) Azetidine-2-carboxylic acid | L-Aze

Storage

Room temperature

Shipped In

Normal

Overview

Product Description：

 L-Azetidine-2-carboxylic acid is a non-protein amino acid and teratogenic agent. It is toxic in nature.

Product Application：
L-Azetidine-2-carboxylic acid has been used as a: collagen synthesis inhibitor protein folding antagonist as a standard in liquid chromatography-mass spectrometry

Specifications

Synonyms

(S)-2-Azetidinecarboxylic acid | 02A | 2-Azetidinecarboxylic acid, (2S)- | AM20090185 | C08267 | (S)-Azetidine-2-carboxylicacid | CHEBI:6198 | L-Azetidine 2-carboxylic acid | SR-01000075656-1 | UNII-5GZ3E0L9ZU | (S)-(-) Azetidine-2-carboxylic acid | L-Aze

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

It is an inhibitor of collagen synthesis that is anti-angiogenic. It is a four-membered ring analog of L-proline that causes protein misconstruction when incorporated instead of proline.

Storage

Room temperature

Shipped In

Normal

Grade

Moligand™

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488182253
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488182253
• Canonical Smiles: C1CNC1C(=O)O
• IUPAC Name: (2S)-azetidine-2-carboxylic acid
• InChIKey: IADUEWIQBXOCDZ-VKHMYHEASA-N
• INCHI: 1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1
• Isomeric SMILES: C1CN[C@@H]1C(=O)O
• WGK Germany: 3
• RTECS: CM4310500
• Molecular Weight: 101.1
• Beilstein: 80680
• Reaxy-Rn: 80680
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=80680&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Azetidinecarboxylic acids Amino acids Monocarboxylic acids and derivatives Dialkylamines Carboxylic acids Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: L-alpha-amino acid - Azetidinecarboxylic acid - Azetidine - Amino acid - Carboxylic acid - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Secondary amine - Organoheterocyclic compound - Azacycle - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Amine - Organic oxygen compound - Carbonyl group - Organopnictogen compound - Hydrocarbon derivative - Organic oxide - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: azetidine-2-carboxylic acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)

Discover Target: SLC36A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solubility in Water almost transparency
• Specific Rotation[α]: -122°
• Melt Point(°C): 217℃
• Molecular Weight: 101.100 g/mol
• XLogP3: -2.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 101.048 Da
• Monoisotopic Mass: 101.048 Da
• Topological Polar Surface Area: 49.300 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 91.700
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1