Beta-secretase

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  1. beta-Secretase Inhibitor II (Z-VLL-CHO)
    CAS: 263563-09-3 PubChem CID: 10253763 Molecular Weight: 461.6
    Out of Stock Item #: S276273
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    SMILES
    CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
    Synonyms
    benzylN-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxobutan...
  2. AZD3293 (Lanabecestat), Inhibitor of beta-secretase 1
    CAS: 1383982-64-6 Formula: C26H28N4O Molecular Weight: 412.53
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: A276027
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    SMILES
    CC#CC1=CC(=CN=C1)C2=CC3=C(CC4(C35N=C(C(=N5)N)C)CCC(CC4)OC)C=C2
    InChIKey
    WKDNQONLGXOZRG-BOPKNSRXSA-N
    InChI
    1S/C26H28N4O/c1-4-5-18-12-21(16-28-15-18)19-6-7-20-14-25(10-8-22(31-3)9-11-25)26(23(20)13-19)29-17(2)24(27)30-26/h6-7,12-13,15-16,22H,8-11,14H2,1-3H3,show more
    Synonyms
    (1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]...
  3. Eslicarbazepine Acetate, Sodium channel alpha subunit blocker
    CAS: 236395-14-5 EC Number: 636-617-2 Formula: C17H16N2O3 Molecular Weight: 296.32
    In Stock Item #: E133192
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    IUPAC Name
    [(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate
    SMILES
    CC(=O)OC1CC2=CC=CC=C2N(C3=CC=CC=C13)C(=O)N
    InChIKey
    QIALRBLEEWJACW-INIZCTEOSA-N
    InChI
    1S/C17H16N2O3/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16/h2-9,16H,10H2,1H3,(H2,18,21)/t16-/m0/s1
    Synonyms
    5'-Chloro-alpha(sup 4)-(p-chlorophenyl)-alpha(sup 4)-cyano-3,5-diiodo-2',4'-salicyloxylidide | EN300-18665321 | (S)-(...
  4. AZD3839, Inhibitor of beta-secretase 1
    CAS: 1227163-84-9 EC Number: 682-619-1 Formula: C24H16F3N5 Molecular Weight: 431.4
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: A275977
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    IUPAC Name
    (3S)-3-[2-(difluoromethyl)pyridin-4-yl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine
    SMILES
    C1=CC(=CC(=C1)C2(C3=C(C(=CC=C3)F)C(=N2)N)C4=CC(=NC=C4)C(F)F)C5=CN=CN=C5
    InChIKey
    MRXBCEQZNKUUIP-DEOSSOPVSA-N
    InChI
    1S/C24H16F3N5/c25-19-6-2-5-18-21(19)23(28)32-24(18,17-7-8-31-20(10-17)22(26)27)16-4-1-3-14(9-16)15-11-29-13-30-12-15/h1-13,22H,(H2,28,32)/t24-/m0/s1
    Synonyms
    AZD 3839 | AZD 3839 [WHO-DD] | AZD3839 | AZD-3839 | 1H-Isoindol-3-amine, 1-(2-(difluoromethyl)-4-pyridinyl)-4-fluoro-...
  5. Bicinchoninic acid disodium salt(BCA)
    CAS: 979-88-4 EC Number: 629-761-2 PubChem CID: 164763 Formula: C20H10N2Na2O4· xH2O Molecular Weight: 388.28 (anhydrous basis)
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: B107658
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    IUPAC Name
    disodium;2-(4-carboxylatoquinolin-2-yl)quinoline-4-carboxylate
    SMILES
    O.[Na+].[Na+].[O-]C(=O)c1cc(nc2ccccc12)-c3cc(C([O-])=O)c4ccccc4n3
    InChIKey
    AUPXFICLXPLHBB-UHFFFAOYSA-L
    InChI
    1S/C20H12N2O4.2Na/c23-19(24)13-9-17(21-15-7-3-1-5-11(13)15)18-10-14(20(25)26)12-6-2-4-8-16(12)22-18;;/h1-10H,(H,23,24)(H,25,26);;/q;2*+1/p-2
    Synonyms
    BCA | B5838 | BCADisodium | B4509 | AKOS015951447 | Bicinchoninic Acid Disodium Salt [for Protein Research] | DISODIU...
  6. Se-(Methyl)seleno-L-cysteine
    CAS: 26046-90-2 PubChem CID: 147004 Formula: C4H9NO2Se Molecular Weight: 182.08
    In Stock Item #: S161277
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    IUPAC Name
    (2R)-2-amino-3-methylselanylpropanoic acid
    SMILES
    C[Se]CC(C(=O)O)N
    InChIKey
    XDSSPSLGNGIIHP-VKHMYHEASA-N
    InChI
    1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
    Synonyms
    methyl-L-selenocysteine | (2R)-2-amino-3-methylselanylpropanoic acid | 2-Amino-3-methylselenyl propionic acid | DB126...
  7. LX-2343
    CAS: 333745-53-2 Formula: C22H19ClN2O6S Molecular Weight: 474.91
    In Stock Item #: L276484
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    IUPAC Name
    2-[N-(benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide
    SMILES
    COC1=C(C=C(C=C1)Cl)N(CC(=O)NC2=CC3=C(C=C2)OCO3)S(=O)(=O)C4=CC=CC=C4
    InChIKey
    ZGYSGIYKAVUVOR-UHFFFAOYSA-N
    InChI
    1S/C22H19ClN2O6S/c1-29-19-9-7-15(23)11-18(19)25(32(27,28)17-5-3-2-4-6-17)13-22(26)24-16-8-10-20-21(12-16)31-14-30-20/h2-12H,13-14H2,1H3,(H,24,26)
    Synonyms
    N-(benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide | 2-[N-(Benzenesulfonyl)-5-ch...
  8. LY2811376, Inhibitor of beta-secretase 1
    CAS: 1194044-20-6 Formula: C15H14F2N4S Molecular Weight: 320.36
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: L128069
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    IUPAC Name
    (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
    SMILES
    CC1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F
    InChIKey
    MJQMRGWYPNIERM-HNNXBMFYSA-N
    InChI
    1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1
    Synonyms
    s1528 | MJQMRGWYPNIERM-HNNXBMFYSA-N | (4S)-4-[2,4-DIFLUORO-5-(PYRIMIDIN-5-YL)PHENYL]-4-METHYL-5,6-DIHYDRO-1,3-THIAZIN...
  9. LY2886721, Inhibitor of beta-secretase 1
    CAS: 1262036-50-9 Formula: C18H16F2N4O2S Molecular Weight: 390.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: L125253
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    IUPAC Name
    N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
    SMILES
    C1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N
    InChIKey
    NIDRNVHMMDAAIK-YPMLDQLKSA-N
    InChI
    1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6,10H,7-9H2,(H2,21,24)(H,23,25)/t10-,18-/m0/sshow more
    Synonyms
    AS-56127 | MFCD22124078 | AC-33097 | (benzyloxycarbonyl)-glycine | BCP02507 | N-{3-[(4as,7as)-2-Amino-4a,5-Dihydro-4h...
  10. LY 2886721 Hydrochloride
    CAS: 1262036-49-6 PubChem CID: 50902942 Formula: C18H16F2N4O2S.HCl Molecular Weight: 426.87
    Out of Stock Item #: L287726
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    Technical Identifiers
    IUPAC Name
    N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide;hydrochloride
    SMILES
    C1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N.Cl
    InChIKey
    JHHMCINLHBUFHB-GHDSXOKHSA-N
    InChI
    1S/C18H16F2N4O2S.ClH/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18;/h1-6,10H,7-9H2,(H2,21,24)(H,23,25);1H/t10-,show more
    Synonyms
    LY2886721 HYDROCHLORIDE | LY-2886721 hydrochloride | LY 2886721 hydrochloride | UNII-HW8GJY7V7R | N-[3-[(4aS,7aS)-2-a...
  11. Verubecestat (MK-8931), Beta-secretase 1 inhibitor
    CAS: 1286770-55-5 EC Number: 813-681-1 Formula: C17H17F2N5O3S Molecular Weight: 409.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: M276428
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    IUPAC Name
    N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide
    SMILES
    CC1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F
    InChIKey
    YHYKUSGACIYRML-KRWDZBQOSA-N
    InChI
    1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1
    Synonyms
    DTXSID301020622 | GTPL8699 | N-{3-[(5r)-3-Amino-2,5-Dimethyl-1,1-Dioxido-5,6-Dihydro-2h-1,2,4-Thiadiazin-5-Yl]-4-Fluo...
  12. Se-(Methyl)selenocysteine hydrochloride
    CAS: 863394-07-4 PubChem CID: 11957622 Formula: C4H10ClNO2Se Molecular Weight: 218.54
    Out of Stock Item #: S171281
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    IUPAC Name
    (2R)-2-amino-3-methylselanylpropanoic acid;hydrochloride
    SMILES
    C[Se]CC(C(=O)O)N.Cl
    InChIKey
    JMPVTFHGWJDSDV-DFWYDOINSA-N
    InChI
    1S/C4H9NO2Se.ClH/c1-8-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H/t3-;/m0./s1
    Synonyms
    Se-(Methyl)Selenocysteine HCl | Se-Methylseleno-L-cysteine Hydrochloride | EU-0100799 | Se-(Methyl)selenocysteine hyd...
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