Lin28 1632 - ≥98%(HPLC) , CAS No.108825-65-6

CAS: 108825-65-6 Cat. No.: L287258 Molecular Weight: 281.31

GRADE & PURITY ≥98%(HPLC)

Synonyms

Lin28 1632 | Lin-28 1632 | N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]-pyridazin-6-yl)phenyl]acetamide | N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide | CCG-42206 | DTXSID20371981 | HMS1448E05 | Lin281632 | Lin-281632 | WP

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product Describtion:

Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells.

Specifications

Synonyms

Lin28 1632 | Lin-28 1632 | N-methyl-N-[3-(3-methyl-1, 2, 4-triazolo[4, 3-b]-pyridazin-6-yl)phenyl]acetamide | N-Methyl-N-[3-(3-methyl-1, 2, 4-triazolo[4, 3-b]pyridazin-6-yl)phenyl]acetamide | CCG-42206 | DTXSID20371981 | HMS1448E05 | Lin281632 | Lin-281632 | WP

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

RNA binding protein Lin28 inhibitor (IC50= 8μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Increaseslet-7miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Inhibit

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 488192879
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488192879
• Canonical Smiles: CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
• IUPAC Name: N-methyl-N-[3-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
• InChIKey: WPAQLESUVYGUJZ-UHFFFAOYSA-N
• INCHI: 1S/C15H15N5O/c1-10-16-17-15-8-7-14(18-20(10)15)12-5-4-6-13(9-12)19(3)11(2)21/h4-9H,1-3H3
• Isomeric SMILES: CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
• Molecular Weight: 281.31
• Reaxy-Rn: 13479104
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13479104&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Diazines
      • Subclass Pyridazines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Diazines
• Subclass: Pyridazines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridazines
• Alternative Parents: Acetanilides Triazolopyridazines Triazoles Tertiary carboxylic acid amides Heteroaromatic compounds Acetamides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylpyridazine - Acetanilide - Triazolopyridazine - Anilide - Monocyclic benzene moiety - Benzenoid - Azole - Tertiary carboxylic acid amide - 1,2,4-triazole - Acetamide - Heteroaromatic compound - Carboxamide group - Carboxylic acid derivative - Azacycle - Organopnictogen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Carbonyl group - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylpyridazines. These are organic compounds containing a pyridazine ring substituted by a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

Discover Target: BRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 28.13, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 28.13, Max Conc. mM: 100
• Molecular Weight: 281.310 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 281.128 Da
• Monoisotopic Mass: 281.128 Da
• Topological Polar Surface Area: 63.400 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 390.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1