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· · COA & SDS available for every product · Same-day shipping on in-stock items Lomeguatrib - 10mM in DMSO , CAS No.192441-08-0
GRADE & PURITY 10mM in DMSO
Synonyms
NSC787251 | NSC-787251 | 6-(4-Bromothenyloxy)-7H-purin-2-amine | 6-((4-bromothiophen-2-yl)methoxy)-9H-purin-2-amine | Lomeguatrib [INN] | S79265T71M | SMR004701339 | 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine | HY-13668 | Lomeguatrib, >=98% (HPLC) |
Shipped In
Dry ice packs + Cold packs
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Why this grade 10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
Specifications Synonyms
NSC787251 | NSC-787251 | 6-(4-Bromothenyloxy)-7H-purin-2-amine | 6-((4-bromothiophen-2-yl)methoxy)-9H-purin-2-amine | Lomeguatrib [INN] | S79265T71M | SMR004701339 | 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine | HY-13668 | Lomeguatrib, >=98% (HPLC) |
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Lomequartrib is an inhibitor of O6 methylguanin-DNA methyltransferase (MGMT) with an IC50 value of 0.009 μM in cell-free extracts from HeLa S3 cells.Potent O 6 -methylguanine-DNA methyltransferase (MGMT) inhibitor (IC 50 = 9 nM). Inhibits recombinant huma
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N IUPAC Name 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine InChIKey JUJPKFNFCWJBCX-UHFFFAOYSA-N INCHI 1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16) Isomeric SMILES C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N WGK Germany 3 RTECS UO7420000 Molecular Weight 326.17 Reaxy-Rn 26263521 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26263521&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Imidazopyrimidines Subclass Purines and purine derivatives Intermediate Tree Nodes Purinones Direct Parent Hypoxanthines Alternative Parents Aminopyrimidines and derivatives Alkyl aryl ethers Aryl bromides Thiophenes Imidazoles Heteroaromatic compounds Azacyclic compounds Primary amines Organobromides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Hypoxanthine - Alkyl aryl ether - Aminopyrimidine - Aryl bromide - Aryl halide - Pyrimidine - Heteroaromatic compound - Azole - Imidazole - Thiophene - Azacycle - Ether - Organobromide - Organohalogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Primary amine - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as hypoxanthines. These are compounds containing the purine derivative 1H-purin-6(9H)-one. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Molecular Weight 326.170 g/mol XLogP3 2.000 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 3 Exact Mass 324.963 Da Monoisotopic Mass 324.963 Da Topological Polar Surface Area 118.000 Ų Heavy Atom Count 18 Formal Charge 0 Complexity 299.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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