Menadione sodium bisulfite - BioReagent, for cell culture, ≥95%(TLC) , CAS No.130-37-0

CAS: 130-37-0 Cat. No.: M475321 Molecular Weight: 276.24 EC Number: 204-987-0

GRADE & PURITY BioReagent, for Cell culture, ≥95%(TLC)

Synonyms

AKOS016352717 | DTXCID8020547 | FT-0633931 | Hemoklot | Sepisol | 2-Methyl-1,4-naphthochinon-natrium-bisulfit trihydrat | Menadione bisulfite sodium | Menadione sodium bisulfite [INN] | SHB 264AB | 1,2,3,4-Tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfon

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Description

Use in cell culture to induce oxidative stress for mechanistic studies.

Specifications

Synonyms

AKOS016352717 | DTXCID8020547 | FT-0633931 | Hemoklot | Sepisol | 2-Methyl-1, 4-naphthochinon-natrium-bisulfit trihydrat | Menadione bisulfite sodium | Menadione sodium bisulfite [INN] | SHB 264AB | 1, 2, 3, 4-Tetrahydro-2-methyl-1, 4-dioxo-2-naphthalenesulfon

Specifications & Purity

BioReagent, for cell culture, ≥95%(TLC)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

BioReagent, for Cell culture

Note

Water soluble vitamin K3.

Purity

≥95%(TLC)

Names and Identifiers

• Canonical Smiles: CC1(CC(=O)C2=CC=CC=C2C1=O)S(=O)(=O)[O-].[Na+]
• IUPAC Name: sodium;2-methyl-1,4-dioxo-3H-naphthalene-2-sulfonate
• InChIKey: XDPFHGWVCTXHDX-UHFFFAOYSA-M
• INCHI: 1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
• Isomeric SMILES: CC1(CC(=O)C2=CC=CC=C2C1=O)S(=O)(=O)[O-].[Na+]
• Molecular Weight: 276.24
• Reaxy-Rn: 3922400
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3922400&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Naphthalenes
      • Subclass Naphthoquinones

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Naphthalenes
• Subclass: Naphthoquinones
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthoquinones
• Alternative Parents: Tetralins Quinones Aryl alkyl ketones Sulfonyls Organosulfonic acids Alkanesulfonic acids Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Naphthoquinone - Tetralin - Quinone - Aryl ketone - Aryl alkyl ketone - Alkanesulfonic acid - Sulfonyl - Organosulfonic acid - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Ketone - Organic alkali metal salt - Organic salt - Organic oxygen compound - Organic oxide - Organosulfur compound - Organooxygen compound - Organic sodium salt - Hydrocarbon derivative - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as naphthoquinones. These are compounds containing a naphthohydroquinone moiety, which consists of a benzene ring linearly fused to a bezene-1,4-dione (quinone).
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cenchrus americanus (77 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: water: soluble 50mg/mL, clear, colorless to light yellow
• Melt Point(°C): 121-124°C
• Molecular Weight: 276.240 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 276.007 Da
• Monoisotopic Mass: 276.007 Da
• Topological Polar Surface Area: 99.700 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 466.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Xinlei Lu, Cai Long, Kun Jia, Jialin Yang, Xue Yu, Yuhang Ge, Jingtao Zhao, Jing Hong, Ruizhen Zhang, Xinming Jia, Yongquan Qing, Miao Yu, Yunli Zhao.  (2024)  Design of dry/wet-loaded drug composite materials with sandwich structure for efficient synergistic hemostasis.  Applied Materials Today,      [PMID:] [10.1016/j.apmt.2024.102457]