ML 120B dihydrochloride - ≥95% , CAS No.1782573-78-7

CAS: 1782573-78-7 Cat. No.: M287871 Molecular Weight: 439.72 PubChem CID: 90488985

GRADE & PURITY ≥95%

Synonyms

N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

N-(6-Chloro-7-methoxy-9H-pyrido[3, 4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Novel, ATP-competitive IKK2-selective inhibitor (IC50= 60 nM at 50μM ATP). Exhibits no inhibition at IKK1 (EC50>100μM), IKKε(EC50>100μM) or a panel of 28 other kinases (EC50>50μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates sy

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CC1=C(C=CC=N1)C(=O)NC2=C3C(=CC(=C2OC)Cl)C4=C(N3)C=NC=C4.Cl.Cl
• IUPAC Name: N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylpyridine-3-carboxamide;dihydrochloride
• InChIKey: AWKOVWFBTRXQLW-UHFFFAOYSA-N
• INCHI: 1S/C19H15ClN4O2.2ClH/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16;;/h3-9,23H,1-2H3,(H,24,25);2*1H
• Isomeric SMILES: CC1=C(C=CC=N1)C(=O)NC2=C3C(=CC(=C2OC)Cl)C4=C(N3)C=NC=C4.Cl.Cl
• PubChem CID: 90488985
• Molecular Weight: 439.72

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 8.79, Max Conc. mM: 20; Solvent:water, Max Conc. mg/mL: 2.2, Max Conc. mM: 5 with gentle warming