N-Phenylthiourea - Moligand™, ≥98% , Agonist of TAS2R38, CAS No.103-85-5, Agonist of TAS2R38

CAS: 103-85-5 Cat. No.: P110661 Molecular Weight: 152.22 Beilstein Registry Number: 907309 EC Number: 203-151-2
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
1-PHENYL-2-THIOUREA | Phenylthiocarbamide | Fenylthiomocovina [Czech] | NSC5779 | NSC-5779 | FT-0608239 | RCRA waste no. P093 | URS | N-Phenylthiourea, >=98% | N-Phenylthiourea, 97% | 6F82C6Q54C | F3143-0088 | NCGC00259231-01 | Phenylthioharnstoff | VU051
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5g
P110661-5g
5
$10.90
25g
P110661-25g
3
$41.90
100g
P110661-100g
1
$150.90
500g
P110661-500g
2
$392.90
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 43 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

A useful biochemical for proteomics research.

Specifications

Synonyms
1-PHENYL-2-THIOUREA | Phenylthiocarbamide | Fenylthiomocovina [Czech] | NSC5779 | NSC-5779 | FT-0608239 | RCRA waste no. P093 | URS | N-Phenylthiourea, >=98% | N-Phenylthiourea, 97% | 6F82C6Q54C | F3143-0088 | NCGC00259231-01 | Phenylthioharnstoff | VU051
Specifications & Purity
Moligand™, ≥98%
Storage
Room temperature
Shipped In
Normal
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of TAS2R38
Purity
≥98%
Names and Identifiers
Pubchem Sid488191052
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488191052
Canonical SmilesC1=CC=C(C=C1)NC(=S)N
IUPAC Namephenylthiourea
InChIKeyFULZLIGZKMKICU-UHFFFAOYSA-N
INCHI1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
Isomeric SMILES C1=CC=C(C=C1)NC(=S)N
WGK Germany 3
RTECS YU1400000
Alternate CAS 103-85-5
NSC Number 5779
UN Number 2811
Packing Group I
MeSH Entry Terms Phenylthiocarbamide;Phenylthiourea
Molecular Weight 152.22
Beilstein 907309
Reaxy-Rn 907309
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=907309&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassN-phenylthioureas
Intermediate Tree Nodes Not available
Direct ParentN-phenylthioureas
Alternative Parents Thioureas  Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents N-phenylthiourea - Thiourea - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as n-phenylthioureas. These are compounds containing a N-phenylthiourea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a thiourea group.
External Descriptors thioureas
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
TAS2R38 Tchem Taste receptor type 2 member 38 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CXCL8 Tchem Interleukin-8 (642 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
B16 (5829 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dapE Succinyl-diaminopimelate desuccinylase (42 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot NumberCertificate TypeDateItem
G2416237Certificate of AnalysisMay 06, 2024 P110661
C2330259Certificate of AnalysisMar 09, 2023 P110661
K2513028Certificate of AnalysisMar 09, 2023 P110661
K2429103Certificate of AnalysisMar 09, 2023 P110661
G2508140Certificate of AnalysisMar 09, 2023 P110661
G2429016Certificate of AnalysisMar 09, 2023 P110661
E2516105Certificate of AnalysisMar 09, 2023 P110661
C2330280Certificate of AnalysisMar 09, 2023 P110661
C2330272Certificate of AnalysisMar 09, 2023 P110661
C2330271Certificate of AnalysisMar 09, 2023 P110661
C2330248Certificate of AnalysisMar 09, 2023 P110661
C2330246Certificate of AnalysisMar 09, 2023 P110661
C2327421Certificate of AnalysisMar 09, 2023 P110661
B2210559Certificate of AnalysisJan 07, 2022 P110661
C2314541Certificate of AnalysisJan 07, 2022 P110661
B2311344Certificate of AnalysisJan 07, 2022 P110661
B2210567Certificate of AnalysisJan 07, 2022 P110661
B2210565Certificate of AnalysisJan 07, 2022 P110661
B2210564Certificate of AnalysisJan 07, 2022 P110661

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Chemical and Physical Properties
SolubilitySoluble in hot water and alcohol.
SensitivityMoisture sensitive.
Melt Point(°C)154°C
Molecular Weight152.220 g/mol
XLogP30.700
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass152.041 Da
Monoisotopic Mass152.041 Da
Topological Polar Surface Area70.100 Ų
Heavy Atom Count10
Formal Charge0
Complexity119.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Xin Wang, Shoulin Li, Cheng Zhang, Wenping Xu, Mengqi Wu, Jiagao Cheng, Zhong Li, Liming Tao, Yang Zhang.  (2023)  Stereoselective toxicity of acetochlor chiral isomers on the nervous system of zebrafish larvae.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:37992503] [10.1016/j.jhazmat.2023.133016]
2. Xinlei Zhang, Fei Wu, Guicun Li, Lei Wang, Jianfeng Huang, Aili Song, Alan Meng, Zhenjiang Li.  (2023)  Construction of intramolecular donor–acceptor type carbon nitride for photocatalytic hydrogen production.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:37951001] [10.1016/j.jcis.2023.10.152]
3. Xiufang Yan, Xiaoyu Ma, Daoxin Dai, Xiaojuan Yan, Xingyan Han, Xijun Bao, Qiufang Xie.  (2023)  Potent pigmentation inhibitory activity of incensole-enriched frankincense volatile oil-identification, efficacy and mechanism.  Journal of Cosmetic Dermatology,  23  (1): (244-255).  [PMID:37430475] [10.1111/jocd.15887]
4. Kang Xin-Le, Li Yan-Xue, Dong Du-Juan, Wang Jin-Xing, Zhao Xiao-Fan.  (2023)  20-Hydroxyecdysone counteracts insulin to promote programmed cell death by modifying phosphoglycerate kinase 1.  BMC BIOLOGY,  21  (1): (1-17).  [PMID:37226192] [10.1186/s12915-023-01621-2]
5. Tingting Hou, Zaizhao Wang, Kui Tang, Shuai Zhang, Shilin Liu, Jialiang Liu, Xiaoteng Fan, Xiaolin Liu.  (2023)  The Fin-Improving Effects of Fucosylated Chondroitin Sulfate from Green and Purple Apostichopus japonicus on Caudal Fin Regeneration of Zebrafish Larvae.  AQUACULTURE RESEARCH,      [PMID:] [10.1155/2023/9258423]
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11. Zhang Yan, Wang Yanfei, Yao Xuebo, Wang Changquan, Chen Fangyi, Liu Dong, Shao Ming, Xu Zhigang.  (2020)  Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish.  Frontiers in Cell and Developmental Biology,      [PMID:33392193] [10.3389/fcell.2020.604026]
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14. Runren Jiang, Guanghua Lu, Jianchao Liu, Donghai Wu, Zhenhua Yan, Yonghua Wang.  (2020)  Incorporation of π-conjugated molecules as electron donors in g-C3N4 enhances photocatalytic H2-production.  RENEWABLE ENERGY,      [PMID:] [10.1016/j.renene.2020.09.040]
15. Danting Wang, Yuhuan Zhang, Jieyi Li, Randy A. Dahlgren, Xuedong Wang, Haishan Huang, Huili Wang.  (2020)  Risk assessment of cardiotoxicity to zebrafish (Danio rerio) by environmental exposure to triclosan and its derivatives.  ENVIRONMENTAL POLLUTION,      [PMID:32554097] [10.1016/j.envpol.2020.114995]
16. Hongling Zhou, Huihui Cao, Yuanru Zheng, Zibin Lu, Yuyao Chen, Dongyi Liu, Huayi Yang, Jingyu Quan, Chuying Huo, Junshan Liu, Linzhong Yu.  (2019)  Liang-Ge-San, a classic traditional Chinese medicine formula, attenuates acute inflammation in zebrafish and RAW 264.7 cells.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:31778782] [10.1016/j.jep.2019.112427]
17. Jiang Zhu, Kai Tian, Christopher A. Reilly, Xinghui Qiu.  (2019)  Capsaicinoid metabolism by the generalist Helicoverpa armigera and specialist H. assulta: Species and tissue differences.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:31973854] [10.1016/j.pestbp.2019.11.013]
18. Caihong Wang, Wenhao Huang, Jiebo Lin, Fang Fang, Xuedong Wang, Huili Wang.  (2019)  Triclosan-induced liver and brain injury in zebrafish (Danio rerio) via abnormal expression of miR-125 regulated by PKCα/Nrf2/p53 signaling pathways.  CHEMOSPHERE,      [PMID:31627110] [10.1016/j.chemosphere.2019.125086]
19. Jinfeng Liu, Chenyan Xiang, Wenhao Huang, Jingyi Mei, Limei Sun, Yuhang Ling, Caihong Wang, Xuedong Wang, Randy A. Dahlgren, Huili Wang.  (2018)  Neurotoxicological effects induced by up-regulation of miR-137 following triclosan exposure to zebrafish (Danio rerio).  AQUATIC TOXICOLOGY,      [PMID:30496951] [10.1016/j.aquatox.2018.11.017]
20. Jinfeng Liu, Limei Sun, Hongqin Zhang, Mengru Shi, Randy A. Dahlgren, Xuedong Wang, Huili Wang.  (2017)  Response mechanisms to joint exposure of triclosan and its chlorinated derivatives on zebrafish (Danio rerio) behavior.  CHEMOSPHERE,      [PMID:29874755] [10.1016/j.chemosphere.2017.11.106]
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26. Ying Ren, Yue Wang, Yang Wang, Xia Ning, Guangke Li, Nan Sang.  (2024)  Exposure to oxygenated polycyclic aromatic hydrocarbons and endocrine dysfunction: Multi-level study based on hormone receptor responses.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:39700954] [10.1016/j.jhazmat.2024.136855]
27. Xin Wang, Bo Peng, Cheng Zhang, Mengqi Wu, Wenping Xu, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang.  (2024)  Hepatic effects of acetochlor chiral isomers in zebrafish and L02 cells.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:38176547] [10.1016/j.scitotenv.2023.169781]
28. Lingyu Ren, Yue Wang, Ying Ren, Guangke Li, Nan Sang.  (2024)  Phenanthrene perturbs hematopoietic development and causes hematopoietic defects in zebrafish.  Journal of Environmental Sciences,      [PMID:39481963] [10.1016/j.jes.2024.02.018]
29. Yonghui Su, Shanshan Xu, Xinqi Hu, Ruifen Wang, Mengxuan Dong, Yihan Wang, Songsong Wang, Yougang Zhang, Qingping Tian, Liwen Han.  (2024)  Rapid discovery of natural skin-lightening ingredients based on an integrated screening strategy based on molecular docking and zebrafish model.  Journal of Cosmetic Dermatology,      [PMID:38923657] [10.1111/jocd.16439]
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35. Jiao Wu, Xiaoyan Du, Fangchao Tong, Shuangling Zhang, Jiaojie Guo, Changchun Zhu, Rui Cui, Qirong Bai, Mengyao Chen, Li Meng, Linlin Song, Haichuan Yu.  (2025)  Chemical profiling, discriminant analysis, antioxidants, and anti-inflammatory activities of Lonicerae Japonicae Flos tea varieties.  Future Foods,      [PMID:] [10.1016/j.fufo.2025.100642]
36. Weijie Pan, Qianru Chen, Menghua Wu, Yue Sun, Ming Li, Shumei Wang, Xingyang Xue, Jiang Meng.  (2025)  Identifying of Anticoagulant Ingredients From Moutan Cortex Based on Spectrum-Effect Relationship Analysis Combined With GRA, PLS, and SVM Algorithms.  BIOMEDICAL CHROMATOGRAPHY,  39  (5): (e70060).  [PMID:40091648] [10.1002/bmc.70060]
37. Jia-Qiang Yang, Tao Song, Zhao-Yun Wang, Lei Jin, Yi Zhao, Ren Hu, Jian-Jia Su, Fang-Zu Yang, Dongping Zhan, Lianhuan Han.  (2025)  In-operando visualization of the dynamic microvia copper filling process for metal interconnection of integrated circuit.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2025.146698]
38. Zhao-Yun Wang, Li-Xin Yu, Yu-Qing Feng, Lei Jin, Jia-Qiang Yang, Yi Zhao, Tao Song, DongPing Zhan, Daquan Yu, Fang-Zu Yang, Shi-Gang Sun.  (2025)  Study on the Action Mechanism of a Nontraditional Thioamide-Based Leveler of 1-Phenyl 2-Thiourea for Microvia Void-Free Filling.  ACS Applied Materials & Interfaces,      [PMID:40262106] [10.1021/acsami.5c04034]
39. Fan Yang, Hua Wang, Dan Luo, Jun Deng, Yawen Hu, Zhi Liu, Wei Liu.  (2025)  Sialic Acid-Loaded Nanoliposomes with Enhanced Stability and Transdermal Delivery for Synergistic Anti-Aging, Skin Brightening, and Barrier Repair.  Pharmaceutics,  17  (8): (956).  [PMID:40870979] [10.3390/pharmaceutics17080956]
40. Xiuru Zhang, Zhuangzhuang Liu, Yuna Li, Jingqin He, Lulu Yang, Yulin Yan, Shanshan Tong, Yeqi Wang, Tao Zhang.  (2025)  Lead acetate (PbAc) impairs blood-brain barrier in zebrafish via MMP-9/13-induced pericyte developmental defects.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:41138449] [10.1016/j.ecoenv.2025.119250]
41. Fei Fang, Bo Peng, Yanjuan Zhu, Wenping Xu, Yang Zhang, Jiagao Cheng.  (2025)  Bixafen-induced immunotoxicity in zebrafish: TLR4/NF-κB activation and DNA replication disruption as critical pathways.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:41252974] [10.1016/j.ecoenv.2025.119400]
42. Yuyan Jiang, Yijian Chen, Zeri Huang, Lian Chen, Xiao Huang.  (2026)  Tyrosinase-Deficient Skin Melanophore Lineage in Xenopus tropicalis Tadpoles Shows Strong Autofluorescence.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  27  (3): (1367).  [PMID:41683796] [10.3390/ijms27031367]
43. Mengting Xu, Yunmiao Ma, Mengxin Liu, Yueqiu Chen, Zongyi Duan, Zhenya Shen, Yanchao Han.  (2026)  Bmp16 Regulates Arterial Valve Morphogenesis Through Modulation of Notch Signaling in Zebrafish.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  27  (5): (2111).  [PMID:41828338] [10.3390/ijms27052111]
Solution Calculators
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