(-)-Nicotine ditartrate - ≥98% , CAS No.65-31-6

CAS: 65-31-6 Cat. No.: N274769 Molecular Weight: 462.41 EC Number: 200-607-2

GRADE & PURITY ≥98%

Synonyms

Nicotine ditartrate | Nicotine dihydrogen ditartrate | (-)-Nicotine hydrogen tartrate salt | Nicotine hydrogen tartrate | Nicotine Bi-L-(+)-tartrate | Nikotinbitartrat

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice,FedEx DG Service

Overview

Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

Synonyms

Nicotine ditartrate | Nicotine dihydrogen ditartrate | (-)-Nicotine hydrogen tartrate salt | Nicotine hydrogen tartrate | Nicotine Bi-L-(+)-tartrate | Nikotinbitartrat

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Biological description': "Potent nicotinic acetylcholine receptor (nAChR) agonist. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions. Reduces beta-amyloidosis in a mouse model of Alzheimer's disease.

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice, FedEx DG Service

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504766826
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504766826
• Canonical Smiles: CN1CCCC1C2=CN=CC=C2.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O
• IUPAC Name: (2R,3R)-2,3-dihydroxybutanedioic acid;3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
• InChIKey: RFEJUZJILGIRHQ-OMDKHLBYSA-N
• INCHI: 1S/C10H14N2.2C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;2*5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t10-;2*1-,2-/m011/s1
• Isomeric SMILES: CN1CCC[C@H]1C2=CN=CC=C2.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
• UN Number: 1659
• Packing Group: II
• Molecular Weight: 462.41
• Reaxy-Rn: 6495418
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6495418&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pyridines and derivatives
      • Subclass Pyrrolidinylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pyridines and derivatives
• Subclass: Pyrrolidinylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrrolidinylpyridines
• Alternative Parents: Alkaloids and derivatives Sugar acids and derivatives Short-chain hydroxy acids and derivatives Aralkylamines Beta hydroxy acids and derivatives Alpha hydroxy acids and derivatives N-alkylpyrrolidines Monosaccharides Dicarboxylic acids and derivatives Fatty acids and conjugates Heteroaromatic compounds Secondary alcohols Trialkylamines Carboxylic acids Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Not available
• Substituents: Pyrrolidinylpyridine - Alkaloid or derivatives - Beta-hydroxy acid - Aralkylamine - Sugar acid - Short-chain hydroxy acid - Alpha-hydroxy acid - Dicarboxylic acid or derivatives - Hydroxy acid - Monosaccharide - Fatty acid - N-alkylpyrrolidine - Heteroaromatic compound - Pyrrolidine - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - Azacycle - Carboxylic acid - Carboxylic acid derivative - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organic oxygen compound - Alcohol - Organic nitrogen compound - Amine - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrrolidinylpyridines. These are compounds containing a pyrrolidinylpyridine ring system, which consists of a pyrrolidine ring linked to a pyridine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water to 100 mM
• Molecular Weight: 462.400 g/mol
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 7
• Exact Mass: 462.149 Da
• Monoisotopic Mass: 462.149 Da
• Topological Polar Surface Area: 246.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 281.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Naiyan Lu, Xue Mei, Xu Li, Xue Tang, Guofeng Yang, Wen Xiang.  (2023)  Preventive effects of caffeine on nicotine plus high-fat diet-induced hepatic steatosis and gain weight: a possible explanation for why obese smokers with high coffee consumption tend to be leaner.  BRITISH JOURNAL OF NUTRITION,      [PMID:38149470] [10.1017/S0007114523002969]

2. Yuemei Chen, Yang Yu, Shaohan Wang, Jiajia Han, Mengge Fan, Yanping Zhao, Junlang Qiu, Xin Yang, Fang Zhu, Gangfeng Ouyang.  (2023)  Molecularly imprinted polymer sheathed mesoporous silica tube as SPME fiber coating for determination of tobacco-specific nitrosamines in water.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:37806576] [10.1016/j.scitotenv.2023.167655]

3. Zhe Chen, Naiyan Lu, Xu Li, Qingrun Liu, Yujie Li, Xiyue Li, Ximiao Yu, Haotian Zhao, Chang Liu, Xue Tang, Xun Wang, Weisun Huang.  (2024)  The Effect of a Caffeine and Nicotine Combination on Nicotine Withdrawal Syndrome in Mice.  Nutrients,  16  (18): (3048).  [PMID:39339647] [10.3390/nu16183048]

4. Fuqin He, Yongjun Liu, Ruiying Yu, Tianli Zhang, Fang Guo, Xiayu Wu, Yi Fan, Xuedong Zhu, Qianyi Zhou, Dan Shu.  (2025)  Tobacco ethanol extract accelerates wound healing through anti-inflammation and promoting angiogenesis.  Cutaneous and Ocular Toxicology,      [PMID:40966382] [10.1080/15569527.2025.2559680]