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PF 04217903 mesylate - ≥98%(HPLC) , CAS No.956906-93-7

CAS: 956906-93-7 Cat. No.: P288839 Molecular Weight: 468.49 PubChem CID: 24852079
COA
PF 04217903 mesylate - ≥98%(HPLC) CAS No(956906-93-7) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY ≥98%(HPLC)
Synonyms
2-(4-{1-[(quinolin-6-yl)methyl]-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1H-pyrazol-1-yl)ethan-1-ol; methanesulfonic acid | PF-04217903 methanesulfonate | methanesulfonic acid;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol | P
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
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Size
Status
Price
Qty
5mg
P288839-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$57.90
10mg
P288839-10mg
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$82.90
25mg
P288839-25mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$114.90
50mg
P288839-50mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$171.90
100mg
P288839-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$274.90
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
🧪

Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).

Application：

PF-04217903 has been used as tyrosine-protein kinase Met (C-Met) selective inhibitor in Madin-Darby Canine kidney (MDCK) cells[1] and NT2D1 non-seminoma cells.

Specifications

Synonyms
2-(4-{1-[(quinolin-6-yl)methyl]-1H-[1, 2, 3]triazolo[4, 5-b]pyrazin-6-yl}-1H-pyrazol-1-yl)ethan-1-ol; methanesulfonic acid | PF-04217903 methanesulfonate | methanesulfonic acid;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4, 5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol | P
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Highly selective, high affinity MET inhibitor (Ki= 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%(HPLC)
Names and Identifiers
Canonical SmilesCS(=O)(=O)O.C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
IUPAC Namemethanesulfonic acid;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
InChIKeyHBEMHKVWZJTVOC-UHFFFAOYSA-N
INCHI1S/C19H16N8O.CH4O3S/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16;1-5(2,3)4/h1-5,8-10,12,28H,6-7,11H2;1H3,(H,2,3,4)
Isomeric SMILES CS(=O)(=O)O.C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
PubChem CID 24852079
Molecular Weight 468.49

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassQuinolines and derivatives
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentQuinolines and derivatives
Alternative Parents Pyridines and derivatives  Pyrazines  Benzenoids  Triazoles  Sulfonyls  Pyrazoles  Organosulfonic acids  Methanesulfonates  Heteroaromatic compounds  Alkanesulfonic acids  Azacyclic compounds  Alkanolamines  Primary alcohols  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkNot available
Substituents Quinoline - Pyrazine - Pyridine - Benzenoid - Azole - Methanesulfonate - Pyrazole - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - 1,2,3-triazole - Alkanesulfonic acid - Heteroaromatic compound - Alkanolamine - Azacycle - Organic oxygen compound - Organic oxide - Alcohol - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Primary alcohol - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHO (4503 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilitySolvent:DMSO, Max Conc. mg/mL: 46.85, Max Conc. mM: 100
SensitivityMoisture sensitive
Molecular Weight468.500 g/mol
XLogP3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Exact Mass468.133 Da
Monoisotopic Mass468.133 Da
Topological Polar Surface Area170.000 Ų
Heavy Atom Count33
Formal Charge0
Complexity617.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Solution Calculators
Reviews

Customer Reviews

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