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· · COA & SDS available for every product · Same-day shipping on in-stock items PF 06273340 - 10mM in DMSO , CAS No.1402438-74-7
GRADE & PURITY 10mM in DMSO
Synonyms
I136775ABW | 3-(4-Chlorobenzoyl)propionic acid, 96% | BCP29619 | N-{5-[2-Amino-7-(1-Hydroxy-2-Methylpropan-2-Yl)-7h-Pyrrolo[2,3-D]pyrimidine-5-Carbonyl]pyridin-3-Yl}-2-(5-Chloropyridin-2-Yl)acetamide | N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-py
Shipped In
Dry ice packs + Cold packs
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Why this grade 10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
I136775ABW | 3-(4-Chlorobenzoyl)propionic acid, 96% | BCP29619 | N-{5-[2-Amino-7-(1-Hydroxy-2-Methylpropan-2-Yl)-7h-Pyrrolo[2, 3-D]pyrimidine-5-Carbonyl]pyridin-3-Yl}-2-(5-Chloropyridin-2-Yl)acetamide | N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-py
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Potent and selective pan-Trk inhibitor (IC50values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammato
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles CC(C)(CO)N1C=C(C2=CN=C(N=C21)N)C(=O)C3=CC(=CN=C3)NC(=O)CC4=NC=C(C=C4)Cl IUPAC Name N-[5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl]-2-(5-chloropyridin-2-yl)acetamide InChIKey BPIWZDNVMQQBQX-UHFFFAOYSA-N INCHI 1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30) Isomeric SMILES CC(C)(CO)N1C=C(C2=CN=C(N=C21)N)C(=O)C3=CC(=CN=C3)NC(=O)CC4=NC=C(C=C4)Cl PubChem CID 66571548 Molecular Weight 479.93
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Pyridines and derivatives Subclass Pyridinecarboxylic acids and derivatives Intermediate Tree Nodes Not available Direct Parent Pyridinecarboxylic acids and derivatives Alternative Parents Pyrrolo[2,3-d]pyrimidines Aryl ketones N-arylamides Aminopyrimidines and derivatives Substituted pyrroles Aryl chlorides Vinylogous amides Heteroaromatic compounds Secondary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Primary amines Organic oxides Organochlorides Primary alcohols Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Pyrrolo[2,3-d]pyrimidine - Pyridine carboxylic acid or derivatives - Pyrrolopyrimidine - Aryl ketone - N-arylamide - Aminopyrimidine - Aryl chloride - Aryl halide - Pyrimidine - Substituted pyrrole - Heteroaromatic compound - Vinylogous amide - Pyrrole - Amino acid or derivatives - Carboxamide group - Ketone - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Primary alcohol - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Alcohol - Amine - Carbonyl group - Organic oxide - Organic oxygen compound - Primary amine - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. These are compounds containing a pyridine ring bearing a carboxylic acid group or a derivative thereof. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Molecular Weight 479.900 g/mol XLogP3 0.700 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 7 Exact Mass 479.147 Da Monoisotopic Mass 479.147 Da Topological Polar Surface Area 149.000 Ų Heavy Atom Count 34 Formal Charge 0 Complexity 741.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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