PI3K/AKT-IN-1 - 10mM in DMSO , CAS No.P661661(DMSO)

CAS: P661661(DMSO) Cat. No.: P661661 Molecular Weight: 465.52

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

PI3K/AKT-IN-1 is an effective PI3K / AKT dual inhibitor ( IC 50 of 6.99, 4.01 and 3.36 μM for PI3Kγ , PI3Kδ and AKT , respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis

IC50& Target:PI3Kγ 6.99 μM (IC 50 ) PI3Kδ 4.01 μM (IC 50 )

In Vitro:PI3K/AKT-IN-1 (compound 7f) (0.04-100 µM; 48 hours) has high cytotoxic activity on both cell lines with better activity on leukaemia cell line (K562 IC 50 =2.62 µM) than on the breast cancer cell line (MCF-7 IC 50 =3.22 µM). PI3K/AKT-IN-1 (2.62 µM) c

In Vivo:PI3K/AKT-IN-1 (2000mg/kg; p.o.; single) is non-toxic and is well tolerated by experimental animals. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female rats (180-200g)Dosage: 2000

Biological Activity:PI3K/AKT-IN-1 is an effective PI3K / AKT dual inhibitor ( IC 50 of 6.99, 4.01 and 3.36 μM for PI3Kγ , PI3Kδ and AKT , respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis

Specifications

Specifications & Purity

10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: N#CC1=C(N/N=C/C2=CC(OC)=C(OC)C(OC)=C2)N=C(SC)N=C1C3=CC=C(OC)C=C3
• Molecular Weight: 465.52