PI3K/mTOR Inhibitor-2 - 10mM in DMSO , CAS No.1848242-58-9

CAS: 1848242-58-9 Cat. No.: P655747 Molecular Weight: 478.86 PubChem CID: 118616775
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
P655747-1ml
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$526.90
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

PI3K/mTOR Inhibitor-2 is a potent dual pan- PI3K / mTOR inhibitor with IC 50 s of 3.4/34/16/1 nM for PI3Kα / PI3Kβ / PI3Kδ / PI3Kγ and 4.7 nM for mTOR Antitumor activity

In Vitro

PI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC 50 s of 11.6 and 89.2 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PI3Kα 3.4 nM (IC 50 ) PI3Kβ 34 nM (IC 50 ) PI3Kδ 16 nM (IC 50 ) PI3Kγ 1 nM (IC 50 ) mTOR 4.7 nM (IC 50 )

Specifications

Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
PI3K/mTOR Inhibitor-2 is a potent dual pan- PI3K / mTOR inhibitor with IC 50 s of 3.4/34/16/1 nM for PI3Kα / PI3Kβ / PI3Kδ / PI3Kγ and 4.7 nM for mTOR. Antitumor activity.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Names and Identifiers
Isomeric SMILES COC1=C(C=C(C=N1)C2=CN3C(=NC=C(C3=O)Cl)C=C2)NS(=O)(=O)C4=C(C=C(C=C4)F)F
PubChem CID 118616775
Molecular Weight 478.86

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
PIK3CG Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PIK3CA Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MTOR Tclin Serine/threonine-protein kinase mTOR (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Solution Calculators
Reviews

Customer Reviews

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