PRMT5-IN-1 hydrochloride - ≥99% , CAS No.P659371

CAS: P659371 Cat. No.: P659371 Molecular Weight: 455.29

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC 50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form c

Appearance:Solid

IC50& Target:IC50: 11 nM (PRMT5/MEP50)

In Vitro:PRMT5 IN-1 (compound 9; 0-500 nM) hydrochlorideinhibits the PRMT5/MEP50 complex [K inact /K I =1.2×10 5 M -1 min -1 ] very rapidly with a K inact of 0.068 min -1 and a good binding affinity (K I =55 nM). PRMT5 IN-1 (0-1000 nM; 3 d; Granta-519 cells)

Biological Activity:PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC 50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form c

Specifications

Specifications & Purity

≥99%

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 455.29