Roxadustat (FG-4592) - Moligand™, 10mM in DMSO , Hypoxia-inducible factor prolyl hydroxylase inhibitor, CAS No.808118-40-3, Hypoxia-inducible factor prolyl hydroxylase inhibitor

CAS: 808118-40-3 Cat. No.: R408843 Molecular Weight: 352.34 EC Number: 813-400-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

ASP1517 | 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Roxadustat (FG-4592) Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis . Phase 3.
In vitro

FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism.

In vivo

Cell Data

cell lines：MCF-7 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

ASP1517 | 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetic acid

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Hypoxia-inducible factor prolyl hydroxylase inhibitor

Product Properties

• ALogP: 3.4

Names and Identifiers

• Isomeric SMILES: CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3
• Molecular Weight: 352.34
• Reaxy-Rn: 11683248
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11683248&ln=

Associated Targets(Human)

EGLN1 Tclin Egl nine homolog 1 (6 Activities)

Discover Target: EGLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Yujing Wang, Min Xiao, Feng Cai, Yang Li, Tianli Shi, Xiaoyan Zhou, Shuhong Tian, Denggao Huang.  (2023)  Roxadustat ameliorates vascular calcification in CKD rats by regulating HIF-2α/HIF-1α.  ENVIRONMENTAL TOXICOLOGY,      [PMID:38156404] [10.1002/tox.24116]

2. Tang Di, Lin Qiang, Li Pei-Wen, Wang Song, Xu Kai, Huang Yue-Sheng, Lu Qi-Ping.  (2025)  FG-4592 combined with PRP significantly accelerates the healing of refractory diabetic wounds by upregulating HIF-1α.  Scientific Reports,  15  (1): (1-14).  [PMID:40275053] [10.1038/s41598-025-99356-3]