sAJM589 - Moligand™,≥95% , CAS No.2089-82-9

CAS: 2089-82-9 Cat. No.: S649393 Formule: C₁₆H₁₀N₂O Poids moléculaire: 246.26 PubChem CID: 135480579

GRADE & PURITY Moligand™, ≥95%

Synonyms

5-Hydroxybenzo[a]phenazine | Benzo[a]phenazin-5-ol | benzo[a]phenazin-5(7H)-one

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC 50 of 1.8 μM

In Vitro

sAJM589 potently disrupts the Myc-Max heterodimer to reduce Myc protein levels in a dose dependent manner, with an IC 50 of 1.8 μM. ?\nsAJM589 suppresses cellular proliferation in diverse Myc-dependent cancer cell lines and anchorage independent growth of Raji cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 1.8 μM (Myc)

Specifications

Synonymes

5-Hydroxybenzo[a]phenazine | Benzo[a]phenazin-5-ol | benzo[a]phenazin-5(7H)-one

Spécifications et pureté

Moligand™,≥95%

Mécanismes biochimiques et physiologiques

sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC 50 of 1.8 μM.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Pureté

≥95%

Noms et identifiants

Sourires canoniques

C1=CC=C2C(=C1)C(=CC3=NC4=CC=CC=C4N=C23)O

IUPAC Name

benzo[a]phenazin-5-ol

InChIKey

WZBDRAAGHRCRKM-UHFFFAOYSA-N

INCHI

1S/C16H10N2O/c19-15-9-14-16(11-6-2-1-5-10(11)15)18-13-8-4-3-7-12(13)17-14/h1-9,19H

Isomères SMILES

C1=CC=C2C(=C1)C(=CC3=NC4=CC=CC=C4N=C23)O

PubChem CID

135480579

Poids moléculaire

246.26

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazanaphthalenes
      • Subclass Benzodiazines
        • Level5 Quinoxalines
          • Level6 Phenazines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Quinoxalines
• Direct Parent: Phenazines and derivatives
• Alternative Parents: Naphthols and derivatives 1-hydroxy-2-unsubstituted benzenoids Pyrazines Secondary ketimines Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenazine - 1-naphthol - Naphthalene - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Pyrazine - Heteroaromatic compound - Secondary ketimine - Ketimine - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Imine - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenazines and derivatives. These are polycyclic aromatic compounds containing a phenazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a pyrazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO : 5 mg/mL (20.30 mM; Need ultrasonic)
• Poids moléculaire: 246.260 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 246.079 Da
• Monoisotopic Mass: 246.079 Da
• Topological Polar Surface Area: 46.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 335.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2089-82-9, the molecular formula is C16H10N2O, and the molecular weight is 246.26 g/mol. InChIKey WZBDRAAGHRCRKM-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.