Sinapic acid - ≥98% , CAS No.530-59-6

CAS: 530-59-6 Cat. No.: S106903 Molecular Weight: 224.21 Beilstein Registry Number: 2699118 EC Number: 208-487-3 PubChem CID: 637775
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
Synapoic acid | trans-3,5-Dimethoxy-4-hydroxycinnamic acid | MS-8962 | 3-(4-hydroxy-3,5-dimethoxyphenyl)acrylic acid | Sinapic acid, >=98%, powder | (E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid | 2-Propenoic acid, 3-(4-hydroxy-3,5-dimethoxypheny
Storage
Store at 2-8°C
Shipped In
Wet ice
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 64 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.

Sinapic acid can be used:
• As a potent peroxynitrite (ONOO−) oxidant scavenger for the protection of the cellular constituents against peroxynitrite cytotoxic species.
• In the synthesis of antioxidant hydroxycinnamic acid xylan esters via esterification reaction.
• In the synthesis of pseudo-cinnamic derivatives effective against mycobacterium tuberculosis

Specifications

Synonyms
Synapoic acid | trans-3, 5-Dimethoxy-4-hydroxycinnamic acid | MS-8962 | 3-(4-hydroxy-3, 5-dimethoxyphenyl)acrylic acid | Sinapic acid, >=98%, powder | (E)-3-(4-Hydroxy-3, 5-dimethoxyphenyl)-2-propenoic acid | 2-Propenoic acid, 3-(4-hydroxy-3, 5-dimethoxypheny
Specifications & Purity
≥98%
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Pubchem Sid488190858
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488190858
Canonical SmilesCOC1=CC(=CC(=C1O)OC)C=CC(=O)O
IUPAC Name(E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
InChIKeyPCMORTLOPMLEFB-ONEGZZNKSA-N
INCHI1S/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13)/b4-3+
Isomeric SMILES COC1=CC(=CC(=C1O)OC)/C=C/C(=O)O
WGK Germany 3
PubChem CID 637775
Molecular Weight 224.21
Beilstein 2699118
Reaxy-Rn 2130006

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassCinnamic acids and derivatives
SubclassHydroxycinnamic acids and derivatives
Intermediate Tree Nodes Not available
Direct ParentHydroxycinnamic acids
Alternative Parents Coumaric acids and derivatives  Cinnamic acids  Methoxyphenols  Dimethoxybenzenes  Styrenes  Phenoxy compounds  Anisoles  Alkyl aryl ethers  Monocarboxylic acids and derivatives  Carboxylic acids  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Cinnamic acid - Coumaric acid or derivatives - Hydroxycinnamic acid - M-dimethoxybenzene - Dimethoxybenzene - Methoxyphenol - Phenoxy compound - Anisole - Methoxybenzene - Styrene - Phenol ether - Alkyl aryl ether - Phenol - Monocyclic benzene moiety - Benzenoid - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Ether - Organic oxygen compound - Carbonyl group - Organic oxide - Organooxygen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as hydroxycinnamic acids. These are compounds containing an cinnamic acid where the benzene ring is hydroxylated.
External Descriptors Sinapate derivatives
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G7 Tchem LDL-associated phospholipase A2 (1338 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMPD1 Tchem Sphingomyelin phosphodiesterase (13561 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Cryz Quinone oxidoreductase (288 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAL62 Alpha-glucosidase MAL62 (106 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ralstonia solanacearum (520 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pyogenes (16140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RBL-2H3 (1162 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lasiodiplodia theobromae (193 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Brain (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aorta (2975 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Diplodia seriata (145 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Diplodia mutila (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Neofusicoccum luteum (172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Botryosphaeria dothidea (71 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Neofusicoccum parvum (61 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Phaeoacremonium minimum (24 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

20 results found

Lot NumberCertificate TypeDateItem
C2624187Certificate of AnalysisApr 01, 2026 S106903
A2622005Certificate of AnalysisJan 28, 2026 S106903
A2604175Certificate of AnalysisJan 06, 2026 S106903
L2519036Certificate of AnalysisDec 30, 2025 S106903
L2511120Certificate of AnalysisDec 20, 2025 S106903
F2215213Certificate of AnalysisDec 12, 2025 S106903
F2215227Certificate of AnalysisDec 12, 2025 S106903
F2215228Certificate of AnalysisDec 12, 2025 S106903
F2509028Certificate of AnalysisJun 16, 2025 S106903
G2315035Certificate of AnalysisApr 08, 2025 S106903
D23261121Certificate of AnalysisFeb 11, 2025 S106903
D23261115Certificate of AnalysisFeb 11, 2025 S106903
D23261107Certificate of AnalysisFeb 11, 2025 S106903
G2412063Certificate of AnalysisJul 18, 2024 S106903
D2508764Certificate of AnalysisJul 01, 2024 S106903
D2508763Certificate of AnalysisJul 01, 2024 S106903
K2118052Certificate of AnalysisSep 14, 2023 S106903
K2118058Certificate of AnalysisSep 14, 2023 S106903
K2118059Certificate of AnalysisSep 14, 2023 S106903
K2118090Certificate of AnalysisSep 14, 2023 S106903

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Chemical and Physical Properties
SolubilityH2O: slightly soluble ; methanol: water: soluble; polar organic solvents: soluble
SensitivityMoisture sensitive
Melt Point(°C)202°C
Molecular Weight224.210 g/mol
XLogP31.500
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass224.068 Da
Monoisotopic Mass224.068 Da
Topological Polar Surface Area76.000 Ų
Heavy Atom Count16
Formal Charge0
Complexity249.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Citations of This Product
References
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20. Jian Zhao, Hewei Li, Wanying Li, Zixian Wang, Zhewen Dong, Huan Lan, Chengqiang Wang, Jia-Le Song.  (2021)  Effects of Sinapic Acid Combined with Cisplatin on the Apoptosis and Autophagy of the Hepatoma Cells HepG2 and SMMC-7721.  Evidence-based Complementary and Alternative Medicine,      [PMID:34675987] [10.1155/2021/6095963]
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