10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 37 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Taxifolin, type I inhibitor forVEGFR-2 kinase, is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
In vitro
Taxifolin is not mutagenic and low toxic compared to Qercetin. It acts as a potential chemopreventive agent by regulating genes via an ARE-dependent mechanism. Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner.
In vivo
Cell Data
cell lines：MIA PaCa-2, H1373, H358, H2122, SW1573, H2030, KYSE-410 cells (G12C); H1299 (WT); A549 (G12S), HCT116 (G13D) cells
Concentrations：
Incubation Time：
Powder Purity:≥96%
| Isomeric SMILES | C1=CC(=C(C=C1[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O |
|---|---|
| Alternate CAS | 17654-26-1 |
| PubChem CID | 439533 |
| Molecular Weight | 304.25 |
| Beilstein | 5299277 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Solubility | Solubility (25°C) In vitro DMSO: 65 mg/mL (198.53 mM); Ethanol: 34 mg/mL (103.84 mM); Water: Insoluble; |
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| Melt Point(°C) | 242 °C |
| 1. Changting Yin, Shanjie Han, Xiaoguo Fang, Chunfeng Jin, Baoyu Han, Mengxin Wang. (2025) Insight into the flavor characteristics and antioxidant activity in Xiaoqinggan black tea. FOOD RESEARCH INTERNATIONAL, [PMID:41174363] [10.1016/j.foodres.2025.117227] |
| 2. Chao-Yue Sun, Wan-Qing Li, Jing-Wen Lu, Ao-Yue Zhang, Qing-Xia Chu, Li Tang, Wei Gao, Jin-Jie Cai, Ying Lu, Dong Liu. (2025) Ampelopsis grossedentata protects against ethanol-induced acute duodenal injury by inhibiting TNF-triggered caspases-dependent apoptosis in mice. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40854417] [10.1016/j.jep.2025.120462] |
| 3. Zepeng Yang, Huangling Wang, Chen Huang, Cui Wang, Zimeng Geng, Fei Lyu. (2025) Size-structured flavonoid distribution in Salix babylonica branches modulates Anoplophora glabripennis feeding behavior: A novel mechanistic target for eco-friendly antifeedant development. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, [PMID:41461405] [10.1016/j.pestbp.2025.106711] |
| 4. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu. (2023) Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies. Food Chemistry-X, [PMID:38144792] [10.1016/j.fochx.2023.101023] |
| 5. Xia Chenjie, Zhu Hongliu, Hu Changhui, Liu Jie, Hua Haibing, Yang Jianqiu, Chen Zhipeng, Gao Yihong. (2023) Simultaneous Determination of Three Flavonoids in Rat Plasma of Masson Pinus Needles (Pinus massoniana L.) Extracts by UHPLC-MS/MS and Application to Pharmacokinetics Studies after Oral and Transdermal Administration. JOURNAL OF CHROMATOGRAPHIC SCIENCE, [PMID:37647634] [10.1093/chromsci/bmad074] |
| 6. Yuan Meng, Zihao Wei, Changhu Xue. (2023) Deciphering the interaction mechanism and binding mode between chickpea protein isolate and flavonoids based on experimental studies and molecular simulation. FOOD CHEMISTRY, [PMID:37454615] [10.1016/j.foodchem.2023.136848] |
| 7. Huiqun Fan, Mingshun Chen, Taotao Dai, Lizhen Deng, Chengmei Liu, Wei Zhou, Jun Chen. (2023) Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential. Food Bioscience, [PMID:] [10.1016/j.fbio.2023.102508] |
| 8. Shi Xia, Fang Jiaxing, Du Huicong, Zhang Sufang, Liu Fu, Zhang Zhen, Kong Xiangbo. (2022) Performance of two Ips bark beetles and their associated pathogenic fungi on hosts reflects a species-specific association in the beetle-fungus complex. Frontiers in Plant Science, [PMID:36483952] [10.3389/fpls.2022.1029526] |
| 9. Leyong Yuan, Yan Sun, Ning Zhou, Weipeng Wu, Weidong Zheng, Yukun Wang. (2022) Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway. Frontiers in Pharmacology, [PMID:35645837] [10.3389/fphar.2022.845600] |
| 10. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
| 11. Chengshuai Li, Lijing Zhang, Decao Niu, Shuzhen Nan, Xiumei Miao, Xiaowei Hu, Hua Fu. (2021) Investigation of flavonoid expression and metabolite content patterns during seed formation of Artemisia sphaerocephala Krasch.. SEED SCIENCE RESEARCH, 31 (2): (136-148). [PMID:] [10.1017/S096025852100012X] |
| 12. Hao Liu, Chenyun Gan, Houyin Shi, Kunyan Qu, Liuyang Jing, Muhe Lu, Benyu Su, Huayang Yu, Hang Yuan, Jingjing Chen, Ruirui Zhang, Weiling Zeng. (2020) Gastric floating pill enhances the bioavailability and drug efficacy of dihydromyricetin in vivo. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.jddst.2020.102279] |
| 13. Chaonan Su, Caihong Li, Kang Sun, Wenjing Li, Rongxia Liu. (2020) Quantitative analysis of bioactive components in walnut leaves by UHPLC-Q-Orbitrap HRMS combined with QAMS. FOOD CHEMISTRY, [PMID:32544651] [10.1016/j.foodchem.2020.127180] |
| 14. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:32480277] [10.1016/j.saa.2020.118519] |
| 15. Wan-Jun Long, Hai-Long Wu, Tong Wang, Ming-Yue Dong, Ru-Qin Yu. (2020) Exploiting second-order advantage from mathematically modeled liquid chromatography–mass spectrometry data for simultaneous determination of polyphenols in Chinese propolis. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2020.105003] |
| 16. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
| 17. Xiaoqin Wang, Wencong Jia, Guoyin Lai, Lijuan Wang, María del Mar Contreras, Daomao Yang. (2020) Extraction for profiling free and bound phenolic compounds in tea seed oil by deep eutectic solvents. JOURNAL OF FOOD SCIENCE, 85 (5): (1450-1461). [PMID:32249418] [10.1111/1750-3841.15019] |
| 18. Yating Lu, Dong Li, Li Li, Tarun Belwal, Yanqun Xu, Xingyu Lin, Zhenhua Duan, Zisheng Luo. (2020) Effects of elevated CO2 on pigment metabolism of postharvest mandarin fruit for degreening. FOOD CHEMISTRY, [PMID:32126463] [10.1016/j.foodchem.2020.126462] |
| 19. Rongxia Liu, Chaonan Su, Yumeng Xu, Kangle Shang, Kang Sun, Caihong Li, Jing Lu. (2020) Identifying potential active components of walnut leaf that action diabetes mellitus through integration of UHPLC-Q-Orbitrap HRMS and network pharmacology analysis. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:32058009] [10.1016/j.jep.2020.112659] |
| 20. Xia Zhang, Danqing Li, Chaoyang Dong, Jianguo Shi, Yangang Sun, Baoxian Ye, Yuandong Xu. (2019) Molybdenum sulfide-based electrochemical platform for high sensitive detection of taxifolin in Chinese medicine. ANALYTICA CHIMICA ACTA, [PMID:31986281] [10.1016/j.aca.2019.11.057] |
| 21. Long Ma, Xiuqi Cao, Haiyue Wang, Kui Lu, Ying Wang, Chunhao Tu, Yujie Dai, Yuanyuan Meng, Yuyin Li, Peng Yu, Shuli Man, Aipo Diao. (2019) Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:30694659] [10.1021/acs.jafc.8b05447] |
| 22. Qian Liu, Hai-Long Wu, Zhi Liu, Rong Xiao, Tong Wang, Yong Hu, Yu-Jie Ding, Ru-Qin Yu. (2018) Chemometrics-assisted HPLC-DAD as a rapid and interference-free strategy for simultaneous determination of 17 polyphenols in raw propolis. Analytical Methods, 10 (46): (5577-5588). [PMID:] [10.1039/C8AY01986J] |
| 23. Shuyu Shen, Rui Huang, Charlie Li, Wenyan Wu, Honglin Chen, John Shi, Shiguo Chen, Xingqian Ye. (2018) Phenolic Compositions and Antioxidant Activities Differ Significantly among Sorghum Grains with Different Applications. MOLECULES, 23 (5): (1203). [PMID:29772811] [10.3390/molecules23051203] |
| 24. Han Peng, Zeyuan Deng, Xuan Chen, Yong Sun, Bing Zhang, Hongyan Li. (2018) Major chemical constituents and antioxidant activities of different extracts from the peduncles of Hovenia acerba Lindl. INTERNATIONAL JOURNAL OF FOOD PROPERTIES, [PMID:] [10.1080/10942912.2018.1497059] |
| 25. Jiang Liu, Xiansheng Wang, Sheng Geng, Benguo Liu, Guizhao Liang. (2017) Inhibitory Mechanism of Taxifolin against α-Glucosidase Based on Spectrofluorimetry and Molecular Docking. Natural Product Communications, [PMID:] [10.1177/1934578X1701201116] |
| 26. Xiaoqin Wang, Qiumei Zeng, María del Mar Contreras, Lijuan Wang. (2017) Profiling and quantification of phenolic compounds in Camellia seed oils: Natural tea polyphenols in vegetable oil. FOOD RESEARCH INTERNATIONAL, [PMID:29195939] [10.1016/j.foodres.2017.09.089] |
| 27. Wang Bohong, Qin Qian, Chang Mengmeng, Li Shuyan, Shi Xianzhe, Xu Guowang. (2017) Molecular interaction study of flavonoids with human serum albumin using native mass spectrometry and molecular modeling. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (3): (827-837). [PMID:28840311] [10.1007/s00216-017-0564-7] |
| 28. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang. (2017) Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr). Journal of Functional Foods, [PMID:] [10.1016/j.jff.2017.03.003] |
| 29. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2016) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, [PMID:28159264] [10.1016/j.foodchem.2016.12.001] |
| 30. Qinqin Wang, Lu Wang, Gaiping Li, Baoxian Ye. (2016) A simple and sensitive method for determination of taxifolin on palladium nanoparticles supported poly (diallyldimethylammonium chloride) functionalized graphene modified electrode. TALANTA, [PMID:28107936] [10.1016/j.talanta.2016.11.045] |
| 31. Wang Weiting, Fan Xuanxuan, Chen Naidong, Hao Jingwen, Zhang Manman, Xie Zhengjun. (2025) An Ultra-High Performance Liquid Chromatography-Mass Spectrometry Method Based on Solid Phase Extraction Was Developed for the Analysis of Polyphenols in Prunus Mume Sieb. et Zucc. JOURNAL OF AOAC INTERNATIONAL, [PMID:40120078] [10.1093/jaoacint/qsaf028] |
| 32. Xiaomeng Zhang, Xinquan Tian, Junyu Luo, Xiaoyang Wang, Shoupu He, Gaofei Sun, Ruidan Dong, Panhong Dai, Xiao Wang, Zhaoe Pan, Baojun Chen, Daowu Hu, Liru Wang, Baoyin Pang, Aishuang Xing, Guoyong Fu, Baoquan Wang, Jinjie Cui, Lei Ma, Xiongming Du. (2025) Identification of UDP-glucosyltransferase involved in the biosynthesis of phloridzin in Gossypium hirsutum. PLANT JOURNAL, 121 (3): (e17248). [PMID:39935137] [10.1111/tpj.17248] |
| 33. Ye Wang, Shao-jie Chen, Ting Ma, Qiu Long, Lan Chen, Ke-xin Xu, Yu Cao. (2024) Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:38924866] [10.1016/j.intimp.2024.112517] |
| 34. Xiaomei Wen, Shanjie Han, Jiahui Wang, Yanxia Zhang, Lining Tan, Chen Chen, Baoyu Han, Mengxin Wang. (2024) The Flavor Characteristics, Antioxidant Capability, and Storage Year Discrimination Based on Backpropagation Neural Network of Organic Green Tea (Camellia sinensis) during Long-Term Storage. Foods, 13 (5): (753). [PMID:38472869] [10.3390/foods13050753] |
| 35. Jiazeng Yang, Jincai Liang, Lei Shao, Lihong Liu, Ke Gao, Jun-Liang Zhang, Zhenjiao Sun, Wendong Xu, Pengcheng Lin, Rongmin Yu, Jiachen Zi. (2020) Green production of silybin and isosilybin by merging metabolic engineering approaches and enzymatic catalysis. METABOLIC ENGINEERING, [PMID:32004707] [10.1016/j.ymben.2020.01.007] |
| 36. Zunqiong Ke, Lishu Lin, Yunhong Long, Wenhui Zhang, Jianmin Guo, Leyong Yuan. (2026) Dihydroquercetin Attenuates Silica‐Induced Pulmonary Fibrosis by Modulating the Gut Microbiota and the Serum Metabolites in Mice. Food Science & Nutrition, 14 (1): (e71389). [PMID:41509197] [10.1002/fsn3.71389] |
| 37. Fangfang Chen, Yihan Cai, Jinxiong Wu, Nengzhen Fang, Fei Li, Hongtan Wu, Yu-Pei Chen. (2026) Multi-Target Photoprotection by Taxifolin Against UVB-Induced Keratinocyte Injury Through UVB Filtration, ROS Scavenging and Transcriptomic-Proteomic Reprogramming. Biomolecules, 16 (3): (387). [PMID:] [10.3390/biom16030387] |
