Tipepidine hydrochloride - ≥99% , CAS No.1449686-84-3

CAS: 1449686-84-3 Cat. No.: T646944 Molecular Weight: 311.89 PubChem CID: 138991192

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D 2 receptor-mediated GIRK currents (I DA(GIRK) ) with an IC 50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect .

In Vivo

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old)Dosage: 10, 20 and 40 mg/kg Administration: I.p.; 0.5, 5, 23 hours Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.

Form:Solid

IC50& Target:IC50: 7.0 μM (dopamine D 2 receptor)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D 2 receptor-mediated GIRK currents (I DA(GIRK) ) with an IC 50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitu

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CN1CCCC(=C(C2=CC=CS2)C3=CC=CS3)C1.Cl
• IUPAC Name: 3-(dithiophen-2-ylmethylidene)-1-methylpiperidine;hydrochloride
• InChIKey: MICLPSFJJVIDJE-UHFFFAOYSA-N
• INCHI: 1S/C15H17NS2.ClH/c1-16-8-2-5-12(11-16)15(13-6-3-9-17-13)14-7-4-10-18-14;/h3-4,6-7,9-10H,2,5,8,11H2,1H3;1H
• PubChem CID: 138991192
• Molecular Weight: 311.89

Chemical and Physical Properties

• Solubility: DMSO : 41.67 mg/mL (133.60 mM; Need ultrasonic) H2O : 3.33 mg/mL (10.68 mM; Need ultrasonic)
• Molecular Weight: 311.900 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 311.057 Da
• Monoisotopic Mass: 311.057 Da
• Topological Polar Surface Area: 59.700 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 308.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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