VGX-1027 (Git-27) - Moligand™, ≥98% , CAS No.6501-72-0

CAS: 6501-72-0 Cat. No.: V275496 Formule: C₁₁H₁₁NO₃ Poids moléculaire: 205.21 Numéro CE: 636-241-9 PubChem CID: 10798271

GRADE & PURITY Moligand™, ≥98%

Synonyms

rac-[(5R)-3-phényl-4,5-dihydro-1,2-oxazol-5-yl]acide acétique | 4,5-Dihydro-3-phényl-5-isoxazole-acide acétique | VGX-1027;GIT 27 | GLS1027 | GLS-1027 | 2-Isoxazoline-5-acetic acid, 3-phenyl- | 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID | AKT814N13R | AS

Storage

Stocker à -20°C, chargé d'argon, desséché

Shipped In

Glacière + blocs de glace

Vue d’ensemble

Conserver à -20°C. Conserver dans des conditions de dessiccation. Le produit peut être conservé jusqu'à 12 mois.

Specifications

Synonymes

rac-[(5R)-3-phényl-4,5-dihydro-1,2-oxazol-5-yl]acide acétique | 4,5-Dihydro-3-phényl-5-isoxazole-acide acétique | VGX-1027;GIT 27 | GLS1027 | GLS-1027 | 2-Isoxazoline-5-acetic acid, 3-phenyl- | 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID | AKT814N13R | AS

Spécifications et pureté

Moligand™, ≥98%

Mécanismes biochimiques et physiologiques

Agent immunomodulateur. Inhibiteur de TLR4. Modulateur des voies de signalisation TLR4 et TLR 2/6. Inhibe la présentation de l'antigène inflammatoire. Inhibe la sécrétion d'IL1-β, d'IL-10, d'IFN-γ et de TNF-α. Montre des effets anti-inflammatoires in vivo

Source

Synthetic

Conditions de stockage de stockage

Stocker à -20°C, chargé d'argon, desséché

Expédié en

Glacière + blocs de glace

Grade

Moligand™

Note

Dans la mesure du possible, les solutions doivent être préparées et utilisées le même jour. Toutefois, si vous devez préparer des solutions de base à l'avance, nous vous recommandons de les conserver sous forme d'aliquotes dans des flacons hermétiques à -20°C. Ces aliquotes sont généralement utilisables pendant un mois. En général, ces solutions peuvent être utilisées pendant un mois. Avant utilisation, et avant d'ouvrir le flacon, nous vous recommandons de laisser votre produit s'équilibrer à température ambiante pendant au moins 1 heure. Besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥98%

Propriétés du produit

• ALogP: 1.3

Noms et identifiants

• Pubchem Sid: 504765623
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504765623
• Sourires canoniques: C1C(ON=C1C2=CC=CC=C2)CC(=O)O
• IUPAC Name: 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
• InChIKey: MUFJHYRCIHHATF-UHFFFAOYSA-N
• INCHI: 1S/C11H11NO3/c13-11(14)7-9-6-10(12-15-9)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,14)
• Isomères SMILES: C1C(ON=C1C2=CC=CC=C2)CC(=O)O
• PubChem CID: 10798271
• Poids moléculaire: 205.21

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzene and substituted derivatives
• Alternative Parents: Isoxazolines Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Monocyclic benzene moiety - Isoxazoline - Carboxylic acid derivative - Carboxylic acid - Oxacycle - Azacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

ARSA Tbio Cerebroside-sulfatase (655 Activities)

Discover Target: ARSA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in ethanol to 100 mM and in DMSO to 100 mM
• Sensibilité: Air Sensitive,Heat Sensitive
• Point de fusion (°C): 157.0 to 161.0 °C
• Poids moléculaire: 205.210 g/mol
• XLogP3: 1.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 205.074 Da
• Monoisotopic Mass: 205.074 Da
• Topological Polar Surface Area: 58.900 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 269.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 6501-72-0, the molecular formula is C11H11NO3, and the molecular weight is 205.21 g/mol. InChIKey MUFJHYRCIHHATF-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.