Zinc Pyrithione - Moligand™, 10mM in DMSO , Activator of K v7.1;Activator of K v7.2;Activator of K v7.4;Activator of K v7.5, CAS No.13463-41-7, Activator of K v7.1;Activator of K v7.2;Activator of K v7.4;Activator of K v7.5

CAS: 13463-41-7 Cat. No.: Z408773 Molecular Weight: 317.7 EC Number: 236-671-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

OM-1563 | Zinc, bis[1-(hydroxy-κO)-2(1H)-pyridinethionato-κS2]-, (T-4)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Zinc Pyrithione Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump .
In vitro

Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn ²⁺ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K_1/2) of about 0.3 mM. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential.

In vivo

Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50)\u2009= 8.27\u2009μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Synonyms

OM-1563 | Zinc, bis[1-(hydroxy-κO)-2(1H)-pyridinethionato-κS2]-, (T-4)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of K v7.1;Activator of K v7.2;Activator of K v7.4;Activator of K v7.5

Names and Identifiers

• WGK Germany: 3
• RTECS: ZH0950000
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 317.7

Associated Targets(Human)

KCNQ4 Tclin Potassium voltage-gated channel subfamily KQT member 4 (1 Activities)

Discover Target: KCNQ4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ5 Tclin Potassium voltage-gated channel subfamily KQT member 5 (1 Activities)

Discover Target: KCNQ5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ2 Tclin Potassium voltage-gated channel subfamily KQT member 2 (1 Activities)

Discover Target: KCNQ2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 (1 Activities)

Discover Target: KCNQ1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 100 mg/mL (153.64 mM)

References

1. Shu Zhou, Shukai Liu, Xiao Meng, Tianqi Liu, Xiaoyong Shi, Rongguo Su.  (2024)  Indirect photodegradation of zinc pyrithione: The effect of chromophoric dissolved organic matter components and seawater factors.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2024.112421]