2-Amino-5-methylthiazole - ≥98% , CAS No.7305-71-7

CAS: 7305-71-7 Cat. No.: A102155 Molecular Weight: 114.17 Beilstein Registry Number: 109603 EC Number: 423-800-5

GRADE & PURITY ≥98%

Synonyms

AM20100697 | A56079 | AKOS000120781 | 2-amino-5-methyl-1,3-thiazole | STR04839 | 7RAB78AF2P | 2-amino-5-methyl thiazole | BDBM50271509 | FT-0611180 | 2-Thiazolamine, 5-methyl- | J-507967 | SCHEMBL160815 | (5-Methylthiazol-2-yl)amine | 2-Amino-5-methylthia

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Product Description
2-Amino-5-methylthiazole is a heterocyclic building block. It is one of the major alkaline metabolite of tenoxicam (TX) and meloxicam (MX).
Product Application
2-Amino-5-methylthiazole may be used in the preparation of acrylamide monomer, 5-methyl-2-thiozyl methacrylamide (MTMAAm). 2-Amino-5-methylthiazole may be used in the preparation of mixed-ligand dien-Cu(II) complexes (dien=diethylenetriamine). It may be used in the preparation of a new series of Schiff mono/dibase coordination compounds, having potential anticancer and antibacterial activities.

Specifications

Synonyms

AM20100697 | A56079 | AKOS000120781 | 2-amino-5-methyl-1, 3-thiazole | STR04839 | 7RAB78AF2P | 2-amino-5-methyl thiazole | BDBM50271509 | FT-0611180 | 2-Thiazolamine, 5-methyl- | J-507967 | SCHEMBL160815 | (5-Methylthiazol-2-yl)amine | 2-Amino-5-methylthia

Specifications & Purity

≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504758564
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504758564
• Canonical Smiles: CC1=CN=C(S1)N
• IUPAC Name: 5-methyl-1,3-thiazol-2-amine
• InChIKey: GUABFMPMKJGSBQ-UHFFFAOYSA-N
• INCHI: 1S/C4H6N2S/c1-3-2-6-4(5)7-3/h2H,1H3,(H2,5,6)
• Isomeric SMILES: CC1=CN=C(S1)N
• WGK Germany: 3
• UN Number: 3077
• Molecular Weight: 114.17
• Beilstein: 109603
• Reaxy-Rn: 109603
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=109603&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azoles
      • Subclass Thiazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azoles
• Subclass: Thiazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: 2,5-disubstituted thiazoles
• Alternative Parents: 2-amino-1,3-thiazoles Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 2,5-disubstituted 1,3-thiazole - 1,3-thiazol-2-amine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Amine - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as 2,5-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at positions 2 and 5 only.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)

Discover Target: NOS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ddlB D-alanylalanine synthetase (66 Activities)

Discover Target: ddlB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase (389 Activities)

Discover Target: murA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in Methanol
• Sensitivity: heat sensitive
• Melt Point(°C): 93-98°C
• Molecular Weight: 114.170 g/mol
• XLogP3: 1.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 114.025 Da
• Monoisotopic Mass: 114.025 Da
• Topological Polar Surface Area: 67.200 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 66.700
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1