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APTO-253 - 10mM in DMSO , CAS No.916151-99-0

APTO-253 - 10mM in DMSO , CAS No.916151-99-0

CAS: 916151-99-0 Cat. No.: A426917 Molecular Weight: 367.38

COA

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APTO-253 - 10mM in DMSO CAS No(916151-99-0) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY 10mM in DMSO

Synonyms

NSC789042 | NSC-789042 | A13838 | 1H-Imidazo(4,5-F)(1,10)phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)- | SCHEMBL10067266 | IrosustatSTX64 | LT-253 | AC-36395 | Lor-253(former code) | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenan

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

🧪

Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

APTO-253 APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21) , promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4) .

Targets

c-Myc ; KLF4

Specifications

Synonyms

NSC789042 | NSC-789042 | A13838 | 1H-Imidazo(4, 5-F)(1, 10)phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)- | SCHEMBL10067266 | IrosustatSTX64 | LT-253 | AC-36395 | Lor-253(former code) | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4, 5-f][1, 10]phenan

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Product Properties

ALogP	4.287
hba_count	3
HBD Count	2
Rotatable Bond	1

Names and Identifiers

Canonical Smiles	CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6
IUPAC Name	2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
InChIKey	NIRXBXIPHUTNNI-UHFFFAOYSA-N
INCHI	1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)
Isomeric SMILES	CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6
Molecular Weight	367.38
Reaxy-Rn	20465211
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20465211&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Phenanthrolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Phenanthrolines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Phenanthrolines
Alternative Parents	Quinolines and derivatives Indoles Benzimidazoles Substituted pyrroles Pyridines and derivatives Benzenoids Aryl fluorides Imidazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Organofluorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	1,10-phenanthroline - Quinoline - Benzimidazole - Indole - Indole or derivatives - Aryl fluoride - Aryl halide - Benzenoid - Substituted pyrrole - Pyridine - Azole - Heteroaromatic compound - Imidazole - Pyrrole - Azacycle - Hydrocarbon derivative - Organic nitrogen compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenanthrolines. These are aromatic polycyclic compounds containing the phenanthroline skeleton, which is a derivative of phenanthrene, and consists of two pyridine rings non-linearly joined by a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

DMSO(mg / mL) Max Solubility	73
DMSO(mM) Max Solubility	198.704338831727
Water(mg / mL) Max Solubility	＜1
Molecular Weight	367.400 g/mol
XLogP3	4.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	367.123 Da
Monoisotopic Mass	367.123 Da
Topological Polar Surface Area	70.300 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	589.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

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