≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Room temperature Ships Normal Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 7 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM. An antagonist of the histamine H1-receptor.
Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an ischemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engageme
Storage
Room temperature
Shipped In
Normal
Action Type
ANTAGONIST
Mechanism of action
Histamine H1 receptor antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as pheniramines. These are compounds containing a pheniramine moiety, which is structurally characterized by the presence of a 2-benzylpyridine linked to an dimethyl(propyl)amine to form a dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine skeleton.
External Descriptors
organic molecular entity
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Xiaohong Zhang, Junfan Niu, Zhiyuan Zhou, Gang Tang, Guangyao Yan, Yulu Liu, Jialu Wang, Gaohua Hu, Jianhua Xiao, Weiyao Yan, Yongsong Cao. (2023) Stimuli-responsive polymeric micelles based on cellulose derivative containing imine groups with improved bioavailability and reduced aquatic toxicity of pyraclostrobin. CHEMICAL ENGINEERING JOURNAL, [PMID:][10.1016/j.cej.2023.145789]
2.Ruike Song, Yanxia Li, Yiting Chen, Zhenli Qiu, Lu Huang. (2023) Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations. JOURNAL OF SEPARATION SCIENCE, 46 (8):(2201039). [PMID:36750206][10.1002/jssc.202201039]
3.Haibo You, Ben Chen, Liqun Fang, Tingting Lin, Ping Xu, Chu Chu, Shengqiang Tong. (2022) Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl-β-cyclodextrin as mobile phase additive. CHIRALITY, 35 (1):(58-66). [PMID:36345792][10.1002/chir.23516]
4.Qi Tang, Long-Xiang He, Xiao-Kun Chu, Bing Yu, Xiang-Ling Gu, You-Qing Shen, Hai-Lin Cong. (2021) Synthesis and enantioseparation characteristics of a novel β-cyclodextrin chiral stationary phase based on diazotized silica in HPLC. FERROELECTRICS, [PMID:][10.1080/00150193.2021.1903260]
5.Xuefeng Li, Chunchen Zhang, Shuting Wu, Xing Chen, John Mai, Ming-Wei Chang. (2019) Precision Printing of Customized Cylindrical Capsules with Multifunctional Layers for Oral Drug Delivery. ACS Applied Materials & Interfaces, [PMID:31573786][10.1021/acsami.9b13568]
6.Qi Tang, Bing Yu, Lilong Gao, Hailin Cong, Shuai Zhang. (2017) Light-assisted preparation of a cyclodextrin-based chiral stationary phase and its separation performance in liquid chromatography. NEW JOURNAL OF CHEMISTRY, 42 (2):(1115-1120). [PMID:][10.1039/C7NJ02911J]
7.Zhen Zhang, Yue Wang, Shuai Lv, Hailin Cong, Youqing Shen, Bing Yu. (2024) Isocyanate-chitin modified microspheres for chiral drug separation in high performance liquid chromatography. JOURNAL OF APPLIED POLYMER SCIENCE, 141 (27):(e55594). [PMID:][10.1002/app.55594]
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