Compound C108 - ≥98% , CAS No.15533-09-2

CAS: 15533-09-2 Cat. No.: C649291 分子式: C₁₅H₁₄N₂O₃ 分子量: 270.28 EC番号: 111-040-4 PubChem CID: 135472588

グレード＆純度 ≥98%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis

In Vitro

Compound C108 (1 μM; 24 h) shows anti-tumor activity against BT474 cells. Compound C108 (4 μM; 24 h) significantly decreases the protein expression of G3BP2 in G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells. Compound C108 (4 μM; 24 h) attenuates ESCC cell metastasis, migration and invasion in KYSE410, KYSE30 and KYSE150 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: G3BP2-overexpressing KYSE410 cells, LINC01554-transfected KYSE30 cells Concentration: 4 μM Incubation Time: 24 h Result: Decreased the protein level of G3BP2 and HDGF.

In Vivo

Compound C108 (1 μM; 24 h) targets and decreases tumor initiating cells (TICs), while injected BT-474 cells treated with Compound C108 into the mammary fat pad of female nonobese diabetic/severe combined immune deficiency (NOD-SCID) mice in a limiting-dilution xenograft assay . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:G3BP2

仕様

仕様と純度

≥98%

生化学的・生理学的メカニズム

Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis

保管条件

Protected from light,Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

INHIBITOR

純度

≥98%

名前と識別子

カノニカル・スマイル

CC(=NNC(=O)C1=CC=CC=C1O)C2=CC=CC=C2O

IUPAC Name

2-hydroxy-N-[(E)-1-(2-hydroxyphenyl)ethylideneamino]benzamide

InChIKey

LQGMBUGEAAGJKW-MHWRWJLKSA-N

INCHI

1S/C15H14N2O3/c1-10(11-6-2-4-8-13(11)18)16-17-15(20)12-7-3-5-9-14(12)19/h2-9,18-19H,1H3,(H,17,20)/b16-10+

PubChem CID

135472588

分子量

270.28

化学的性質と物理的性質

• 溶解度: DMSO : 25 mg/mL (92.50 mM; Need ultrasonic)
• 分子量: 270.280 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 270.1 Da
• Monoisotopic Mass: 270.1 Da
• Topological Polar Surface Area: 81.900 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 370.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1