Crocetin disodium - 10mM in Water , CAS No.591230-99-8

CAS: 591230-99-8 Cat. No.: C656838 Molecular Weight: 372.37 PubChem CID: 10287099

GRADE & PURITY 10mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Crocetin (Transcrocetin) disodium, extracted from saffron ( Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.

In Vitro

Crocetin (Transcrocetin, trans-Crocetin) disodium, a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 µM) reveal no negative significant changes in cellular viability. Crocetin disodium at 10 µM level does not change viability while higher concentrations (40-160 µM) reduces significantly cellular viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NMDA Receptor

Specifications

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

Crocetin (Transcrocetin) disodium, extracted from saffron ( Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Names and Identifiers

• Isomeric SMILES: C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)[O-])/C)/C)/C=C/C=C(/C(=O)[O-])\C.[Na+].[Na+]
• PubChem CID: 10287099
• Molecular Weight: 372.37