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Cyclic Pifithrin-α Hydrobromide - 10mM in DMSO , CAS No.511296-88-1

Cyclic Pifithrin-α Hydrobromide - 10mM in DMSO , CAS No.511296-88-1

Name: Cyclic Pifithrin-α Hydrobromide - 10mM in DMSO , CAS No.511296-88-1
SKU: C424403
Availability: InStock

CAS: 511296-88-1 Cat. No.: C424403 分子式: C₁₆H₁₆N₂S·HBr 分子量: 349.29

COA

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Cyclic Pifithrin-α Hydrobromide - 10mM in DMSO CAS No(511296-88-1) by Aladdin Scientific

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注文可能

GRADE & PURITY 10mM in DMSO

Synonyms

2-(p-tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole HBr | Cyclic Pifithrin-? hydrobromide | A hydrobromide;Cyclic PFT- | AfAE'Adaggeratrade markAfA centA centasA notA em leaderA inverted exclamation mark (hydrobromide) | Cyclic Pifithrin- alpha h

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要 Specifications 名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質ソリューション計算機レビュー

🧪

Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells.

Specifications

同義語

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

Stable, cell-permeable analog of pifithrin-α. Inhibits p53-mediated apoptosis and p53-dependent gene transcription. Prevents dexamethasone-induced cell death in murine thymocytes (EC 50 = 2.01 μM). Potent STAT6 transcriptional inhibitor.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

パブケム・シド	528773286
カノニカル・スマイル	CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br
IUPAC Name	2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide
InChIKey	SGNCOAOESGSEOP-UHFFFAOYSA-N
INCHI	1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13;/h6-10H,2-5H2,1H3;1H
異性体SMILES	CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br
WGKドイツ	3
分子量	349.29
Reaxy-Rn	10212204
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10212204&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 分類 Azoles
    - Subclass Imidazoles
      - Level5 Substituted imidazoles
        Level6 Phenylimidazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
分類	Azoles
Subclass	Imidazoles
Intermediate Tree Nodes	Substituted imidazoles
Direct Parent	Phenylimidazoles
Alternative Parents	Toluenes N-substituted imidazoles Thiazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives Hydrobromides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	4-phenylimidazole - 5-phenylimidazole - Toluene - Benzenoid - N-substituted imidazole - Monocyclic benzene moiety - Heteroaromatic compound - Thiazole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Hydrobromide - Organonitrogen compound - Aromatic heteropolycyclic compound
説明	This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

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レビュー

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感度	Air sensitive ，Heat sensitive ， Light sensitive
分子量	349.300 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	348.03 Da
Monoisotopic Mass	348.03 Da
Topological Polar Surface Area	45.500 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	327.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2