≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC 50 value of 0.6 µM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays
In Vitro
ERCC1-XPF-IN-2 (compound 13) (0-100 µM) shows FEN-1 and DNase I activity with IC 50 s of >100, >100 µM, respectively. ERCC1-XPF-IN-2 slow binding kinetics with an K d value of ~30 µM. ERCC1-XPF-IN-2 shows not toxic to Hep-G2 cells at 10 µM and relatively short mouse and human microsomal half-lives with t 1/2 value of 23 min and 28 min for mouse and human, respectively.\nERCC1-XPF-IN-2 (0-60 µM; 24 h) shows inhibition of nucleotide excision repair (NER) with an IC 50 value of 15.6 μM in A375 cells. ERCC1-XPF-IN-2 (0-60 µM) increases the cisplatin activity with no toxicity. ERCC1-XPF-IN-2 (10 µM; 6h) causes a delay in DNA repair by a right shift towards higher numbers of γH2AX foci per cell. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: A375 cells Concentration: 0-60 µM Incubation Time: Result: Showed no toxicity and increased the cisplatin activity up to 1.5-fold (PF50).
Form:Solid
IC50& Target:ERCC1-XPF
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC 50 value of 0.6 µM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays.
Storage
Protected from light, Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%
Names and Identifiers
Molecular Weight
326.17
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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