G-5555 hydrochloride - ≥98% , CAS No.G658780

CAS: G658780 Cat. No.: G658780 Molecular Weight: 529.42

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 ( PAK1 ) inhibitor with a K i of 3.7 nM.

Appearance:Solid

In Vitro:G-5555 shows excellent kinase selectivity and inhibits only eight out of the 235 kinases tested other than PAK1 with inhibition >70%: PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1. The IC 50 s of G-5555 against SIK2, PAK2, KHS1, MST4, YSK1, MST3 and L

In Vivo:G-5555 exhibits low blood clearance and an acceptable half-life. Good oral exposure (AUC=30 μM•h) and high oral bioavailability (F=80%) are achieved. In an H292 non-small cell lunger cancer (NSCLC) xenograft study in mice, G-5555 inhibits phosphoryla

Biological Activity:G-5555 hydrochloride is a potent and selective p21-activated kinase 1 ( PAK1 ) inhibitor with a K i of 3.7 nM.

Specifications

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O.[H]Cl
• Molecular Weight: 529.42

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (188.89 mM; Need ultrasonic) H2O : 16.67 mg/mL (31.49 mM; Need ultrasonic)