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Hh-Ag1.5 - 10mM in DMSO , CAS No.612542-14-0
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog ( Hh ) agonist with an EC 50 of 1 nM Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure .
In Vitro
HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133 + CD45 - liver stem cells (Hh3A cells) enriched from non-injured liver in vitro. Hh-Ag1.5 competely binds to the Smo-containing membranes with the K i value of 0.52 nM. The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC 50 of 7 nM . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:EC50: 1 nM (Hedgehog)
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog ( Hh ) agonist with an EC 50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
AGONIST
Names and Identifiers
| Isomeric SMILES | CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=C(C=CC(=C5S4)F)F)Cl |
|---|---|
| PubChem CID | 44195701 |
| Molecular Weight | 526.04 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Solution Calculators
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