ISCK03 - 10mM in DMSO , CAS No.945526-43-2

CAS: 945526-43-2 Cat. No.: I427041 Molecular Weight: 355.45 EC Number: 633-636-8

GRADE & PURITY 10mM in DMSO

Synonyms

SCF/c-Kit Signaling Inhibitor | C77268 | HMS3229P07 | AC-35800 | t-Butylphenyl imidazolylphenyl sulfonamide | (4-t-butylphenyl)-N-(4-imidazole-1-yl phenyl)sulfonamide | N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide | HY-101443 | NCGC0038

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

Synonyms

SCF/c-Kit Signaling Inhibitor | C77268 | HMS3229P07 | AC-35800 | t-Butylphenyl imidazolylphenyl sulfonamide | (4-t-butylphenyl)-N-(4-imidazole-1-yl phenyl)sulfonamide | N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide | HY-101443 | NCGC0038

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Cell-permeable, selective SCF/c-Kit inhibitor (IC 50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo. ISCK03 inhibits in vitr

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Canonical Smiles: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
• IUPAC Name: 4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
• InChIKey: XQABBHBFHWHMKF-UHFFFAOYSA-N
• INCHI: 1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
• Isomeric SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
• Molecular Weight: 355.45
• Reaxy-Rn: 11120520
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11120520&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azoles
      • Subclass Imidazoles
        • Level5 Substituted imidazoles
          • Level6 Phenylimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azoles
• Subclass: Imidazoles
• Intermediate Tree Nodes: Substituted imidazoles
• Direct Parent: Phenylimidazoles
• Alternative Parents: Sulfanilides Benzenesulfonamides Phenylpropanes Benzenesulfonyl compounds Organosulfonamides N-substituted imidazoles Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 1-phenylimidazole - Benzenesulfonamide - Sulfanilide - Benzenesulfonyl group - Phenylpropane - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Organosulfonic acid amide - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: light sensitive
• Molecular Weight: 355.500 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 355.135 Da
• Monoisotopic Mass: 355.135 Da
• Topological Polar Surface Area: 72.400 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 522.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1