GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Glycinamide, 1-​(4-​cyano-​2-​pyridinyl)​-​5-​oxo-​L-​prolyl-​2-​(2-​chlorophenyl)​-​N-​(3,​3-​difluorocyclobutyl)​-​N2-​(5-​fluoro-​3-​pyridinyl)​-​, (2S)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Ivosidenib (AG-120) Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) , with potential antineoplastic activity.
In vitro

TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation.

In vivo

Cell Data

cell lines：

Concentrations：0.5, 1.0, and 5.0 μM

Incubation Time：6 days

Powder Purity:≥99%

Specifications

Synonyms

Glycinamide, 1-​(4-​cyano-​2-​pyridinyl)​-​5-​oxo-​L-​prolyl-​2-​(2-​chlorophenyl)​-​N-​(3, ​3-​difluorocyclobutyl)​-​N2-​(5-​fluoro-​3-​pyridinyl)​-​, (2S)​-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor

Product Properties

• ALogP: 3.4

Names and Identifiers

• Isomeric SMILES: C1CC(=O)N([C@@H]1C(=O)N(C2=CC(=CN=C2)F)[C@@H](C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N
• Molecular Weight: 582.96
• Reaxy-Rn: 39859942
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39859942&ln=

Associated Targets(Human)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (9 Activities)

Discover Target: IDH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)