L-Canavanine Sulphate - ≥97%(T) , CAS No.2219-31-0

CAS: 2219-31-0 Cat. No.: L135588 Molecular Weight: 274.25(as Anhydrous) Beilstein Registry Number: 4(3)1637 EC Number: 218-728-4 PubChem CID: 11957500

GRADE & PURITY ≥97%(T)

Synonyms

AKOS024458602 | AI3-52581 | SR-01000597836-1 | Canavanine sulfate | O-carbamimidamido-L-homoserine sulfate | CCG-36451 | CHEBI:78901 | GTPL10346 | HMS3260P22 | L-alpha-Amino-gamma-(guanidinooxy)butyric acid sulfate | (S)-2-Amino-4-(guanidinooxy)butanoic a

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.

Specifications

Synonyms

AKOS024458602 | AI3-52581 | SR-01000597836-1 | Canavanine sulfate | O-carbamimidamido-L-homoserine sulfate | CCG-36451 | CHEBI:78901 | GTPL10346 | HMS3260P22 | L-alpha-Amino-gamma-(guanidinooxy)butyric acid sulfate | (S)-2-Amino-4-(guanidinooxy)butanoic a

Specifications & Purity

≥97%(T)

Biochemical and Physiological Mechanisms

Canavanine is a naturally occurring L-amino acid that competes and interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a su

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%(T)

Names and Identifiers

• Pubchem Sid: 504766823
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504766823
• Canonical Smiles: C(CON=C(N)N)C(C(=O)O)N.OS(=O)(=O)O
• IUPAC Name: (2S)-2-amino-4-(diaminomethylideneamino)oxybutanoic acid;sulfuric acid
• InChIKey: MVIPJKVMOKFIEV-DFWYDOINSA-N
• INCHI: 1S/C5H12N4O3.H2O4S/c6-3(4(10)11)1-2-12-9-5(7)8;1-5(2,3)4/h3H,1-2,6H2,(H,10,11)(H4,7,8,9);(H2,1,2,3,4)/t3-;/m0./s1
• Isomeric SMILES: C(CON=C(N)N)[C@@H](C(=O)O)N.OS(=O)(=O)O
• PubChem CID: 11957500
• Molecular Weight: 274.25(as Anhydrous)
• Beilstein: 4(3)1637
• Reaxy-Rn: 6121291

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Organic sulfuric acids Fatty acids and conjugates Guanidines Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-alpha-amino acid - Sulfuric acid - Fatty acid - Organic sulfuric acid or derivatives - Guanidine - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Amine - Primary amine - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: organic sulfate salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Hygroscopic
• Specific Rotation[α]: 17° (C=2,H2O)
• Melt Point(°C): 160-165°C
• Molecular Weight: 274.260 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 5
• Exact Mass: 274.058 Da
• Monoisotopic Mass: 274.058 Da
• Topological Polar Surface Area: 220.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 259.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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