L-Leucine p-nitroanilide hydrochloride - ≥98% , CAS No.16010-98-3

CAS: 16010-98-3 Cat. No.: L123194 Molecular Weight: 287.74 PubChem CID: 16219558

GRADE & PURITY ≥98%

Synonyms

(2S)-2-amino-4-methyl-N-(4-nitrophenyl)pentanamide;hydrochloride | Pentanamide, 2-amino-4-methyl-N-(4-nitrophenyl)-, hydrochloride (1:1), (2S)- | AKOS015903326 | DTXSID30585198 | L-Leucine p-nitroanilide (hydrochloride) | AM81896 | L-Leucine 4-nitroanilid

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Substrate for the colorimetric determination of leucine aminopeptidase.

Specifications

Synonyms

(2S)-2-amino-4-methyl-N-(4-nitrophenyl)pentanamide;hydrochloride | Pentanamide, 2-amino-4-methyl-N-(4-nitrophenyl)-, hydrochloride (1:1), (2S)- | AKOS015903326 | DTXSID30585198 | L-Leucine p-nitroanilide (hydrochloride) | AM81896 | L-Leucine 4-nitroanilid

Specifications & Purity

≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC(C)CC(C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])N.Cl
• IUPAC Name: (2S)-2-amino-4-methyl-N-(4-nitrophenyl)pentanamide;hydrochloride
• InChIKey: PFOYXOWPGRWPLS-MERQFXBCSA-N
• INCHI: 1S/C12H17N3O3.ClH/c1-8(2)7-11(13)12(16)14-9-3-5-10(6-4-9)15(17)18;/h3-6,8,11H,7,13H2,1-2H3,(H,14,16);1H/t11-;/m0./s1
• Isomeric SMILES: CC(C)C[C@@H](C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])N.Cl
• WGK Germany: 3
• PubChem CID: 16219558
• Molecular Weight: 287.74

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Leucine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Leucine and derivatives
• Alternative Parents: Alpha amino acid amides Anilides Nitrobenzenes Nitroaromatic compounds N-arylamides Fatty amides Secondary carboxylic acid amides Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Monoalkylamines Hydrochlorides Hydrocarbon derivatives Organic oxides Carbonyl compounds Organic zwitterions Organopnictogen compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Leucine or derivatives - Alpha-amino acid amide - Nitrobenzene - Anilide - Nitroaromatic compound - N-arylamide - Monocyclic benzene moiety - Fatty amide - Benzenoid - Fatty acyl - Carboxamide group - C-nitro compound - Secondary carboxylic acid amide - Organic nitro compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organic oxoazanium - Hydrochloride - Primary amine - Organooxygen compound - Organonitrogen compound - Organic oxide - Amine - Primary aliphatic amine - Organopnictogen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic zwitterion - Organic oxygen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as leucine and derivatives. These are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Melt Point(°C): 279-280℃
• Molecular Weight: 287.740 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 287.104 Da
• Monoisotopic Mass: 287.104 Da
• Topological Polar Surface Area: 101.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 293.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Jinxing Liao, Danyu Shen, Long Lin, Hongjun Chen, Yajie Jin, Shan-Ho Chou, Xiao-Quan Yu, Tao Li, Guoliang Qian.  (2021)  Bacterial quorum sensing quenching activity of Lysobacter leucyl aminopeptidase acts by interacting with autoinducer synthase.  Computational and Structural Biotechnology Journal,      [PMID:34900131] [10.1016/j.csbj.2021.11.017]

2. Liu Yucan, Wang Baoyan, Hu Jing, Sun Hongwei, Lv Xintao, Qu Zhiming, Yang Xiaoyong, Wang Gang, Zhang Yanxiang, Zhang Shujun.  (2025)  Effect of Perfluorobutane Sulfonic Acid On Microbial Community and Functional Enzyme of Nitrogen Cycling in Coastal Sediment.  WATER AIR AND SOIL POLLUTION,  236  (12): (1-16).  [PMID:] [10.1007/s11270-025-08433-w]