ROCK

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  1. GSK 269962, Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2
    CAS: 850664-21-0 Formula: C29H30N8O5 Molecular Weight: 570.6
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US Item #: G287476
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    IUPAC Name
    N-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-6-yl]oxyphenyl]-4-(2-morpholin-4-ylethoxy)benzamide
    SMILES
    CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6
    InChIKey
    YOVNFNXUCOWYSG-UHFFFAOYSA-N
    InChI
    1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/show more
    Synonyms
    GTPL8037 | NSC-767348 | SCHEMBL1838346 | UNII-F89KMM7TE2 | N-(3-((2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo...
  2. Narciclasine
    CAS: 29477-83-6 Formula: C14H13NO7 Molecular Weight: 307.26
    ● In Stock — US Item #: N125921
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    IUPAC Name
    (2S,3R,4S,4aR)-2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one
    SMILES
    C1OC2=C(O1)C(=C3C(=C2)C4=CC(C(C(C4NC3=O)O)O)O)O
    InChIKey
    LZAZURSABQIKGB-AEKGRLRDSA-N
    InChI
    1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1
    Synonyms
    Lycoricidin-A | MFCD01729949 | [1,3]Dioxolo[4,5-j]phenanthridin-6(2H)-one, 3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-,...
  3. GSK429286A, Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of ribosomal protein S6 kinase A1
    CAS: 864082-47-3 EC Number: 689-442-9 Formula: C21H16F4N4O2 Molecular Weight: 432.37
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US Item #: G127028
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    IUPAC Name
    N-(6-fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide
    SMILES
    CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F
    InChIKey
    OLIIUAHHAZEXEX-UHFFFAOYSA-N
    InChI
    1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,3show more
    Synonyms
    HMS3244C08 | HMS3654N12 | N6-ethanimidoyl-L-lysine dihydrochloride | dihydropyridone indazole amide 15 | HY-11000 | N...
  4. OXA 06 dihydrochloride
    CAS: 1825455-91-1 PubChem CID: 91691120 Formula: C21H18FN3.2HCl Molecular Weight: 404.31
    ● In Stock — US Item #: O288636
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    IUPAC Name
    N-[(2-fluorophenyl)methyl]-1-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methanamine;dihydrochloride
    SMILES
    C1=CC=C(C(=C1)CNCC2=CC=C(C=C2)C3=C4C=CNC4=NC=C3)F.Cl.Cl
    InChIKey
    ZRBCUSMZOWMVJS-UHFFFAOYSA-N
    InChI
    1S/C21H18FN3.2ClH/c22-20-4-2-1-3-17(20)14-23-13-15-5-7-16(8-6-15)18-9-11-24-21-19(18)10-12-25-21;;/h1-12,23H,13-14H2,(H,24,25);2*1H
    Synonyms
    2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride
  5. 5-(Piperazin-1-ylsulfonyl)isoquinoline
    CAS: 84468-24-6 EC Number: 635-920-7 Formula: C13H15N3O2S Molecular Weight: 277.34
    ● In Stock — US Item #: H275141
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    IUPAC Name
    5-piperazin-1-ylsulfonylisoquinoline
    SMILES
    C1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
    InChIKey
    UPTYCYWTFGTCCG-UHFFFAOYSA-N
    InChI
    1S/C13H15N3O2S/c17-19(18,16-8-6-14-7-9-16)13-3-1-2-11-10-15-5-4-12(11)13/h1-5,10,14H,6-9H2
    Synonyms
    1-(5-Isoquinolinesulfonyl)piperazine | Piperazine, 1-(5-isoquinolinylsulfonyl)- | BDBM15203 | MFCD00209852 | NCGC0002...
  6. Valeric acid
    CAS: 109-52-4 EC Number: 203-677-2 PubChem CID: 7991 Formula: C5H10O2 Molecular Weight: 102.13
    Liquid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%(GC)
    ● In Stock — US Item #: V108272
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    Technical Identifiers
    IUPAC Name
    pentanoic acid
    SMILES
    CCCCC(=O)O
    InChIKey
    NQPDZGIKBAWPEJ-UHFFFAOYSA-N
    InChI
    1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)
    Synonyms
    n-Valeric acid | Pentanoic Acid
  7. Valeric acid
    CAS: 109-52-4 EC Number: 203-677-2 PubChem CID: 7991 Formula: C5H10O2 Molecular Weight: 102.13
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. CP ? Chemically Pure grade — moderate purity above technical grade but below analytical. Use for general lab reactions where ultra-low impurities aren't critical. ≥98%
    ● In Stock — US Item #: V108270
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    Technical Identifiers
    IUPAC Name
    pentanoic acid
    SMILES
    CCCCC(=O)O
    InChIKey
    NQPDZGIKBAWPEJ-UHFFFAOYSA-N
    InChI
    1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)
    Synonyms
    Kyselina valerova | CHEBI:17418 | FT-0694066 | Valeric acid ( Pentanoic acid ) | VALPROIC ACID IMPURITY A [EP IMPURIT...
  8. AS 1892802
    CAS: 928320-12-1 Formula: C20H19N3O2 Molecular Weight: 333.38
    ● In Stock — US Item #: A288609
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    IUPAC Name
    1-[(1S)-2-hydroxy-1-phenylethyl]-3-(4-pyridin-4-ylphenyl)urea
    SMILES
    C1=CC=C(C=C1)C(CO)NC(=O)NC2=CC=C(C=C2)C3=CC=NC=C3
    InChIKey
    WDTFYYZHMRBVHK-LJQANCHMSA-N
    InChI
    1S/C20H19N3O2/c24-14-19(17-4-2-1-3-5-17)23-20(25)22-18-8-6-15(7-9-18)16-10-12-21-13-11-16/h1-13,19,24H,14H2,(H2,22,23,25)/t19-/m1/s1
    Synonyms
    N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea | (S,Z)-N'-(2-hydroxy-1-phenylethyl)-N-(4-(pyridin-4...
  9. RKI 1447 dihydrochloride
    CAS: 1782109-09-4 PubChem CID: 90489001 Formula: C16H14N4O2S.2HCl Molecular Weight: 399.29
    Solid ≥99%(HPLC)
    ● In Stock — US Item #: R287461
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    IUPAC Name
    1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea;dihydrochloride
    SMILES
    C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3.Cl.Cl
    InChIKey
    GBXLRAPHQIRDNS-UHFFFAOYSA-N
    InChI
    1S/C16H14N4O2S.2ClH/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12;;/h1-8,10,21H,9H2,(H2,18,19,20,22);2*1H
    Synonyms
    N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]urea dihydrochloride | 7-Chloro-5-(1H-pyrrol-2-yl)-1H-ben...
  10. Fasudil Hydrochloride
    CAS: 105628-07-7 EC Number: 805-833-0 Formula: C14H17N3O2S·HCl Molecular Weight: 327.83
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US Item #: F122336
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    IUPAC Name
    5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
    SMILES
    C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
    InChIKey
    LFVPBERIVUNMGV-UHFFFAOYSA-N
    InChI
    1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
    Synonyms
    5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride |...
  11. SR 3677
    CAS: 1072959-67-1 EC Number: 802-637-7 PubChem CID: 25093235 Formula: C22H24N4O4 Molecular Weight: 408.45
    ● In Stock — US Item #: S288304
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    IUPAC Name
    N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide
    SMILES
    CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)C3COC4=CC=CC=C4O3
    InChIKey
    OQWZIAVXCYIZNN-UHFFFAOYSA-N
    InChI
    1S/C22H24N4O4/c1-26(2)9-10-28-20-11-15(16-12-23-24-13-16)7-8-17(20)25-22(27)21-14-29-18-5-3-4-6-19(18)30-21/h3-8,11-13,21H,9-10,14H2,1-2H3,(H,23,24)(Hshow more
    Synonyms
    N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
  12. Valeric acid
    CAS: 109-52-4 EC Number: 203-677-2 PubChem CID: 7991 Formula: C5H10O2 Molecular Weight: 102.13
    Analytical standard ? Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods. Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    ● In Stock — US Item #: V108271
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    Technical Identifiers
    IUPAC Name
    pentanoic acid
    SMILES
    CCCCC(=O)O
    InChIKey
    NQPDZGIKBAWPEJ-UHFFFAOYSA-N
    InChI
    1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)
    Synonyms
    Kyselina valerova | CHEBI:17418 | FT-0694066 | Valeric acid ( Pentanoic acid ) | VALPROIC ACID IMPURITY A [EP IMPURIT...
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Frequently Asked Questions

What can I find under ROCK?
This listing collects compounds associated with ROCK within our Stem Cell/Wnt area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for ROCK?
Consider the reported potency of each ROCK compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for ROCK compounds?
Each ROCK product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search ROCK compounds by activity or structure?
Yes. Filter the ROCK listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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