Methylprednisolone (NSC-19987) - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.83-43-2, Glucocorticoid receptor agonist

CAS: 83-43-2 Cat. No.: M409026 Molecular Weight: 374.47 Beilstein Registry Number: 2340300 EC Number: 201-476-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(6α,​11β)​-11,​17,​21-​trihydroxy-​6-​methyl-pregna-​1,​4-​diene-​3,​20-​dione | (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one | U 7532

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Methylprednisolone (NSC-19987) Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical
In vitro

Methylprednisolone (2-10 mg/kg) markedly inhibits TNF production but does not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increases LPS-induced IL-10 levels. Methylprednisolone(from 0.01 to 100 mg/mL) also increases the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages.

In vivo

Methylprednisolone decreases RGC survival in rats with electrophysiologically diagnosed optic neuritis. Methylprednisolone decreases RGC survival by a nongenomic, calcium-dependent mechanism. Methylprednisolone-induced enhancement of RGC degeneration depends on calcium influx through voltage-gated calcium channels. Methylprednisolone treatment leads to a significant decrease in the number of ED1-positive cells in both rostral and caudal stumps. Methylprednisolone treatment results in a significant reduction in tissue loss in both cord stumps at 2, 4 and 8 week post-injury. Methylprednisolone leads to a long-term reduction of ED1-positive cells and spinal tissue loss, reduced dieback of vestibulospinal fibres, and a transient sprouting of vestibulospinal fibres near the lesion at 1 and 2 weeks post-lesion. Methylprednisolone at a dose of 30 mg/kg which has been shown to be effective in improving functional outcomes in rat SCI models, suppresses TNF-α expression and NF-kB activation. Methylprednisolone inhibition of NF-kB function is likely mediated by the induction of IkB, which traps NF-kB in inactive cytoplasmic complexes.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Synonyms

(6α, ​11β)​-11, ​17, ​21-​trihydroxy-​6-​methyl-pregna-​1, ​4-​diene-​3, ​20-​dione | (6S, 8S, 9S, 10R, 11S, 13S, 14S, 17R)-11, 17-dihydroxy-17-(2-hydroxyacetyl)-6, 10, 13-trimethyl-7, 8, 9, 11, 12, 14, 15, 16-octahydro-6H-cyclopenta[a]phenanthren-3-one | U 7532

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone mar

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Glucocorticoid receptor agonist

Product Properties

• ALogP: 1.9

Names and Identifiers

• Isomeric SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
• WGK Germany: 2
• RTECS: TU4146000
• Molecular Weight: 374.47
• Beilstein: 2340300
• Reaxy-Rn: 3463507
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3463507&ln=

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (3 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC5 Tchem Short transient receptor potential channel 5 (1 Activities)

Discover Target: TRPC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Sensitivity: Light sensitive
• Specific Rotation[α]: 82° (C=1,Dioxane)
• Melt Point(°C): 237°C(lit.)

References

1. Fan Xinyu, Zhang Ying, Li Xinyu, Ding Junhui, Huang Jiaolong, Lian Kai, Duan Peng, Hu Chunhui, Xu Junchang.  (2025)  Unraveling Ginsenoside Rg1’s osteoprotective pathways in zebrafish models of glucocorticoid induced osteoporosis via transcriptomics.  Scientific Reports,  15  (1): (1-13).  [PMID:40835685] [10.1038/s41598-025-15284-2]

2. Yuan Liang, Zhuolin Li, Jie Zhang, Tiezhu Li, Chengyu Lv.  (2023)  Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects.  CHEMISTRY & BIODIVERSITY,      [PMID:38129310] [10.1002/cbdv.202301525]

3. Huang Suiyuan, Sun Xuehua, Xin Jianwei, Ma Panpan, Zhang Yuqi, Cai Zhongyu, Wang Ji-Jiang.  (2025)  Molecularly imprinted hydrogels embedded with two-dimensional photonic crystals for the detection of dexamethasone/betamethasone sodium phosphate.  MICROCHIMICA ACTA,  192  (2): (1-11).  [PMID:39878789] [10.1007/s00604-025-06981-w]

4. Taoyang Yuan, Weijie Liu, Tianyou Wang, Feng Ye, Jianhua Zhang, Zhipeng Gu, Jianguo Xu, Yiwen Li.  (2024)  Natural Polyphenol Delivered Methylprednisolone Achieve Targeted Enrichment for Acute Spinal Cord Injury Therapy.  Small,      [PMID:39105462] [10.1002/smll.202404815]

5. Mingyu Cui, Suiyuan Huang, Jianwei Xin, Panpan Ma, Liping Heng, Yuqi Zhang, Ji-Jiang Wang.  (2025)  Molecularly Imprinted Chitosan-Polyvinyl Alcohol Two-Dimensional Photonic Hydrogel for Detecting Hormones.  Advanced Materials Technologies,      [PMID:] [10.1002/admt.202501904]