Minocycline hydrochloride - ≥98% , CAS No.13614-98-7

CAS: 13614-98-7 Cat. No.: M102970 Molecular Weight: 493.94 EC Number: 237-099-7 PubChem CID: 54685925

GRADE & PURITY ≥98%

Synonyms

Minocycline, Hydrochloride | Minocyclinhydrochlorid | BCP06597 | PD003090 | M2288 | Vectrin | MLS002548863 | Q2342917 | ZILXI | DTXSID8044545 | (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetr

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Minocycline hydrochloride has been used: · to prepare nanoliposomes to check its effect on macrophages · for the inhibition of neuroinflammation and neuropathic pain · to treat glioma in murine GL261 glioma cells

Specifications

Synonyms

Minocycline, Hydrochloride | Minocyclinhydrochlorid | BCP06597 | PD003090 | M2288 | Vectrin | MLS002548863 | Q2342917 | ZILXI | DTXSID8044545 | (4S, 4aS, 5aR, 12aS)-4, 7-bis(dimethylamino)-3, 10, 12, 12a-tetrahydroxy-1, 11-dioxo-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydrotetr

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Minocycline acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. M

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504771367
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504771367
• Canonical Smiles: CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
• IUPAC Name: (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
• InChIKey: WTJXVDPDEQKTCV-VQAITOIOSA-N
• INCHI: 1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
• Isomeric SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
• WGK Germany: 3
• RTECS: QI7630500
• PubChem CID: 54685925
• Molecular Weight: 493.94
• Reaxy-Rn: 4836328

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Tetracyclines

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Tetracyclines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Tetracyclines
• Alternative Parents: Naphthols and derivatives Dialkylarylamines 1-hydroxy-2-unsubstituted benzenoids Aralkylamines Cyclohexenones Vinylogous acids Tertiary alcohols Trialkylamines Cyclic alcohols and derivatives Polyols Carboximidic acids Enols Organic oxides Hydrochlorides Hydrocarbon derivatives Organopnictogen compounds
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Tetracycline - 1-naphthol - Naphthalene - Tertiary aliphatic/aromatic amine - Dialkylarylamine - 1-hydroxy-2-unsubstituted benzenoid - Cyclohexenone - Aralkylamine - Benzenoid - Cyclic alcohol - Tertiary alcohol - Vinylogous acid - Ketone - Tertiary amine - Tertiary aliphatic amine - Cyclic ketone - Polyol - Enol - Carboximidic acid derivative - Carboximidic acid - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Alcohol - Organic nitrogen compound - Amine - Hydrochloride - Carbonyl group - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as tetracyclines. These are polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Freely soluble in water
• Sensitivity: Heat sensitive
• Specific Rotation[α]: -170 to -180 deg(C=0.5、0.1mol/L HCl)
• Flash Point(°F): 230°F
• Flash Point(°C): >110℃
• Boil Point(°C): 813℃
• Melt Point(°C): 205-210℃
• Molecular Weight: 493.900 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 3
• Exact Mass: 493.162 Da
• Monoisotopic Mass: 493.162 Da
• Topological Polar Surface Area: 165.000 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 971.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Ting Zhu, Jinyang Chen, Shasha Zeng, Jintao Chen, Chunjiao Qi.  (2023)  Highly Stable Fluorescent-Traffic-Light Sensor for Point-of-Care Detection of Tetracycline.  ACS Sensors,      [PMID:37862265] [10.1021/acssensors.3c01620]

2. Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei.  (2023)  Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model.  International Journal of Nanomedicine,      [PMID:37192894] [10.2147/IJN.S402410]

3. Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Guo.  (2023)  MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization.  Small,      [PMID:36871144] [10.1002/smll.202207335]

4. Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:36244559] [10.1016/j.ijpharm.2022.122285]

5. Ling Yang, Jing Yang, Hua Liu, Jingbin Lan, Ying Xu, Xiaobo Wu, Yushan Mao, Dongming Wu, Kejian Pan, Tao Zhang.  (2022)  Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer.  International Journal of Biological Sciences,      [PMID:35414768] [10.7150/ijbs.70708]

6. Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang.  (2022)  Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke.  PHYTOMEDICINE,      [PMID:35276592] [10.1016/j.phymed.2022.154034]

7. Lijuan Yang, Lumin Zeng, Yongqing Tao, Dandan Wang, Kailian Zhang, Meng Tian, Zhining Xia, Die Gao.  (2021)  Galli Gigerii Endothelium Corneum derived fluorescent carbon dots and their application as sensing platform for nitroimidazoles and cell imaging.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2021.107089]

8. Chengzhi Zhou, Yanlong Sun, Fan Zhang, Yuandong Wu.  (2021)  Degradation of Minocycline by the Adsorption–Catalysis Multifunctional PVDF–PVP–TiO2 Membrane: Degradation Kinetics, Photocatalytic Efficiency, and Toxicity of Products.  International Journal of Environmental Research and Public Health,  18  (23): (12339).  [PMID:34886061] [10.3390/ijerph182312339]

9. Lijuan Yang, Jing Zeng, Tian Quan, Shaochi Liu, Linlin Deng, Xun Kang, Zhining Xia, Die Gao.  (2021)  Liquid-liquid extraction and purification of oil red O derived nitrogen-doped highly photoluminescent carbon dots and their application as multi-functional sensing platform for Cu2+ and tetracycline antibiotics.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2021.106391]

10. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji.  (2019)  Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles.  BIOMATERIALS,      [PMID:31288173] [10.1016/j.biomaterials.2019.119326]

11. Yi Quan, Tan Fang-hui, Tan Jia-an, Chen Xiu-hui, Xiao Qing, Liu Ying-hua, Zhang Gui-ping, Luo Jian-dong.  (2019)  Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation.  ACTA PHARMACOLOGICA SINICA,  40  (8): (1019-1028).  [PMID:30792486] [10.1038/s41401-019-0214-z]

12. Yule Wang, Yiran Li, Yue Zhou, Yue Gao, Lu Zhao.  (2024)  Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization.  Drug Design Development and Therapy,      [PMID:39308695] [10.2147/DDDT.S479881]

13. Binwang Yang, Zhixiong Ye, Feiyu Lu, Jianna Yu, Jiaxu Liu, Xiuqing Zheng, Cheng Wang, Lian Duan, Zhijian Yang, Guoxing Jing, Wen Liu, Wenshan Li, Wenjie Liu.  (2024)  High Resolving Power Electrospray Ionization Ion Mobility Spectrometer Based on Fourier Deconvolution Multiplexing.  ANALYTICAL CHEMISTRY,      [PMID:39413295] [10.1021/acs.analchem.4c04549]

14. Yuwei Zheng, Jiaying Chi, Jiayu Ou, Ling Jiang, Liqing Wang, Rui Luo, Yilang Yan, Zejun Xu, Tingting Peng, Jianfeng Cai, Chuanbin Wu, Peng Teng, Guilan Quan, Chao Lu.  (2024)  Imidazole-Rich, Four-Armed Host-Defense Peptidomimetics as Promising Narrow-Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections.  Advanced Healthcare Materials,      [PMID:39039988] [10.1002/adhm.202400664]

15. Hongchao Dai, Lei Yuan, Luyao Fan, Jia Yang, Xinan Jiao.  (2024)  Occurrence and risk-related features of Bacillus cereus in fluid milk.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,      [PMID:] [10.1111/1471-0307.13054]

16. Yuehong Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu.  (2025)  Intravenously injected poly(amino acid) nanoformulation relieves spinal cord injury through synergistical modulation of microenvironments.  Materials Today Bio,      [PMID:40893356] [10.1016/j.mtbio.2025.102227]

17. Ting Zhu, Yu Yang, Yuhui Shang, Yali Liu, Jinyang Chen.  (2025)  All-in-one prepared highly stable fluorescent copper nanocluster composite for point-of-care sensing of tetracycline.  ANALYTICA CHIMICA ACTA,      [PMID:41093536] [10.1016/j.aca.2025.344688]

18. Pei Wang, Lianguo Wang, Yilan Zhan, Yifan Liu, Ziqiang Chen, Jia Xu, Jun Guo, Jun Luo, Junchao Wei, Fei Tong, Zhihua Li.  (2023)  Versatile hybrid nanoplatforms for treating periodontitis with chemical/photothermal therapy and reactive oxygen species scavenging.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.142293]

19. Xingchen Xu, Pei Wang, Fei Tong, Yifan Liu, Xinyang Hu, Jian Yang, Jun Guo.  (2025)  Polydopamine-Coated Magnetic Nanoplatform for Magnetically Guided Penetration and Enhanced Antibacterial Efficacy in Root Canal Biofilm Elimination.  Polymers,  17  (10): (1305).  [PMID:40430601] [10.3390/polym17101305]

20. Xie Min, Cheng Yu, Yang Lizhen, Lin Zijin, Shen Hao, Zhou Xinhua, Liu Zheng, Xing Jieyu, Zhou Sigui, Chen Haiyun.  (2025)  Tetramethylpyrazine-caffeic Acid Hybrid CT-011 Exerts Dopaminergic Neuroprotection Through Inhibiting Microglia-mediated Neuroinflammation.  MOLECULAR NEUROBIOLOGY,  63  (1): (44).  [PMID:41239042] [10.1007/s12035-025-05310-9]

21. Yu Cheng, Yao Wen, Zhaohan Wang, Lizhen Yang, Junming Liao, Jieyu Xing, Zheng Liu, Xiaoyan Sheng, Lingli Zhou, Sigui Zhou, Jian Zou, Haiyun Chen.  (2026)  Anti-Parkinson's disease polysaccharide PFP50-1 attenuated neuroinflammation via inhibition of TLR4/NF-κB and PI3K/Akt pathways and suppression of NLRP3 inflammasome activation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41616997] [10.1016/j.ijbiomac.2026.150579]