Mocravimod hydrochloride - 10mM in DMSO , CAS No.509088-69-1

CAS: 509088-69-1 Cat. No.: M656009 Molecular Weight: 480.46 EC Number: 859-025-8 PubChem CID: 11155873

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist

In Vivo

Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R ?/? Mice . ?\nMocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Inbred male DA (MHC haplotype: RT1 a ) ratsDosage: 0.1 and 1 mg/kg Administration: Orally; daily; for 100 days Result: Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts.

IC50& Target:S1PR1

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist.

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C=C1)COC2=CC(=CC=C2)SC3=CC(=C(C=C3)CCC(CO)(CO)N)Cl.Cl
• PubChem CID: 11155873
• Molecular Weight: 480.46