Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD).
| Isomeric SMILES | CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)O |
|---|---|
| Molecular Weight | 278.34 |
| Reaxy-Rn | 3206630 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3206630&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Refractive Index | 1.5051 |
|---|
| 1. Yao Yao, Yunshan Zhang, Binqing Xue, Weihua Chu. (2025) Attenuation of MEHP-induced hepatotoxicity and gut microbiota dysbiosis by Lactobacillus brevis Lb-0401 in Carassius auratus. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:40876271] [10.1016/j.scitotenv.2025.180328] |
| 2. Zhen Zhang, Yitong Shang, Hong Yang, Liyang Ding, Yu Deng, Bo Xu, Xufeng Fu. (2025) Lycium barbarum Polysaccharide Improves Iron Homeostasis in Spermatocytes and Sertoli Cells via NRF2 to Alleviate DEHP-Induced Male Reproductive Toxicity in Mice. Toxics, 13 (8): (677). [PMID:40863953] [10.3390/toxics13080677] |
| 3. Yi-bo Wang, Jing-wei Li, Xiao-long Liu, Xin-fei Jiang, Yin-he Lin, Zhi Tian, Jun-jie Yin, Bing-qing Huang, Jia-xin Yang, Chen-xuan Wang, Zi-wang Wu, Shi-xing Ma, Lei Man, Cun-bo Bu, Da-ya Wang. (2025) Separation and recovery of iron from vanadium extraction tailing slag by P204-P507 mixture collector flotation process. Journal of Environmental Chemical Engineering, [PMID:] [10.1016/j.jece.2025.119059] |
| 4. Bo Xu, Tiantian He, Hong Yang, Wenjie Dai, Ling Liu, Xiaoqian Ma, Jiaxue Ma, Guoqin Yang, Rui Si, Xing Du, Xufeng Fu, Xiuying Pei. (2023) Activation of the p62-Keap1-Nrf2 pathway protects against oxidative stress and excessive autophagy in ovarian granulosa cells to attenuate DEHP-induced ovarian impairment in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, [PMID:37776821] [10.1016/j.ecoenv.2023.115534] |
| 5. Yifan Hong, Xiazhu Zhou, Qi Li, Jing Chen, Yuexin Wei, Siyuan Wang, Xiangqin Zheng, Jie Zhao, Chengjun Yu, Jun Pei, Jie Zhang, Chunlan Long, Lianju Shen, Shengde Wu, Guanghui Wei. (2023) Wnt10a downregulation contributes to MEHP-induced disruption of self-renewal and differentiation balance and proliferation inhibition in GC-1 cells: Insights from multiple transcriptomic profiling. ENVIRONMENTAL POLLUTION, [PMID:37364752] [10.1016/j.envpol.2023.122091] |
| 6. Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang. (2022) Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice. Frontiers in Cell and Developmental Biology, [PMID:36438553] [10.3389/fcell.2022.1014243] |
| 7. Fang Guo, Yaoyin Lou, Qun Yan, Jianglei Xiong, Jiahao Luo, Chikang Shen, Dimitris V. Vayenas. (2022) Insight into the Fe–Ni/biochar composite supported three-dimensional electro-Fenton removal of electronic industry wastewater. JOURNAL OF ENVIRONMENTAL MANAGEMENT, [PMID:36327605] [10.1016/j.jenvman.2022.116466] |
| 8. Xiaofang Zhu, Haowei Fu, Jiahui Sun, Qiannan Di, Qian Xu. (2022) N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury. LIFE SCIENCES, [PMID:36174712] [10.1016/j.lfs.2022.121005] |
| 9. Yiwei Fang, Zhiliang Chen, Jinyu Chen, Minqi Zhou, Yuanyao Chen, Rong Cao, Chunyan Liu, Kai Zhao, Min Wang, Huiping Zhang. (2022) Dose–response mapping of MEHP exposure with metabolic changes of trophoblast cell and determination of sensitive markers. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:36152845] [10.1016/j.scitotenv.2022.158924] |
| 10. Jianqiang Sun, Haofeng Zhu, Xindong Yang, Yan Zheng, Tianchi Sun, Honglei Xu, Jiaqi Meng, Anping Zhang. (2022) Carboxylesterase and lipase-catalyzed degradation of phthalate esters in soil and water: Congener structure selectivity and specificity. Environmental Technology & Innovation, [PMID:] [10.1016/j.eti.2022.102571] |
| 11. Yue Leng, Li Ren, Shu Niu, Tiehua Zhang, Jie Zhang. (2021) In vitro and in silico investigations of endocrine disruption induced by metabolites of plasticizers through glucocorticoid receptor. FOOD AND CHEMICAL TOXICOLOGY, [PMID:34273429] [10.1016/j.fct.2021.112413] |
| 12. Jianying Bai, Zhen He, Yaofu Li, Xuexia Jiang, Hongmei Yu, Qing Tan. (2019) Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, [PMID:31004931] [10.1016/j.etap.2019.04.004] |
| 13. Hai-Ming Zhao, Rui-Wen Hu, Xue-Xue Chen, Xue-Bin Chen, Huixiong Lü, Yan-Wen Li, Hui Li, Ce-Hui Mo, Quan-Ying Cai, Ming-Hung Wong. (2018) Biodegradation pathway of di-(2-ethylhexyl) phthalate by a novel Rhodococcus pyridinivorans XB and its bioaugmentation for remediation of DEHP contaminated soil. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:30021277] [10.1016/j.scitotenv.2018.05.334] |
| 14. Zhao Hai-Ming, Hu Rui-Wen, Huang He-Biao, Wen Hong-Fei, Du Huan, Li Yan-Wen, Li Hui, Cai Quan-Ying, Mo Ce-Hui, Liu Jie-Sheng, Wong Ming-Hung. (2017) Enhanced dissipation of DEHP in soil and simultaneously reduced bioaccumulation of DEHP in vegetable using bioaugmentation with exogenous bacteria. BIOLOGY AND FERTILITY OF SOILS, 53 (6): (663-675). [PMID:] [10.1007/s00374-017-1208-y] |
| 15. Hai-Ming Zhao, Huan Du, Jing Lin, Xue-Bin Chen, Yan-Wen Li, Hui Li, Quan-Ying Cai, Ce-Hui Mo, Hua-Ming Qin, Ming-Hung Wong. (2016) Complete degradation of the endocrine disruptor di-(2-ethylhexyl) phthalate by a novel Agromyces sp. MT-O strain and its application to bioremediation of contaminated soil. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:27099998] [10.1016/j.scitotenv.2016.03.171] |
| 16. Bo Xu, Zhen Zhang, Hong Yang, Liyang Ding, Wenjie Dai, Ling Liu, Xing Du, Xufeng Fu, Xiuying Pei. (2024) A novel perspective on di-hexyl phthalate (2-ethylhexyl)-induced reproductive toxicity in females: Lipopolysaccharide synergizes with mono-2-ethylhexyl ester to cause inflammatory apoptosis rather than autophagy in ovarian granulosa cells. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, [PMID:38615642] [10.1016/j.ecoenv.2024.116319] |
| 17. Ning Wang, Nan Zhang, Mei-Ling Sun, Yan Sun, Qing-Yu Dong, Yu Wang, Zeng-Tian Gu, Hai-Tao Ding, Qi-Long Qin, Yong Jiang, Xiu-Lan Chen, Yu-Zhong Zhang, Chao Gao, Chun-Yang Li. (2024) Molecular insights into the catalytic mechanism of a phthalate ester hydrolase. JOURNAL OF HAZARDOUS MATERIALS, [PMID:39013318] [10.1016/j.jhazmat.2024.135191] |
| 18. Yuxing Liao, Huiqiong Liang, Hongmei Huang, Shuangyan Su, Zilin Li, Lijin Huang, Ziyan Yang, Cuixiang Zhang, Han Wang, Guihua Wang, Guiyuan Chen, Xueying Li. (2026) A novel metabolic gene signature induced by Di-(2-ethylhexyl) phthalate and Mono-(2-ethylhexyl) phthalate exposure predicts prognosis in breast cancer: An integrative bioinformatics and experimental study. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, [PMID:41616689] [10.1016/j.ecoenv.2026.119814] |
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